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Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

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Related in: MedlinePlus

Distribution of final best corrected visual acuity (BCVA) and status of foveal involvement and tumor area in the posterior pole according to the type of regression pattern. (A) Distribution of final best corrected visual acuity according to the type of regression pattern. Note that the eyes with type IV regression patterns tended to have better final BCVAs than did those of other regression types. (B) The distributions of foveal involvement and tumor size according to the type of the regression pattern. Note that the eyes with type IV regression patterns tended to have less frequent foveal involvements and smaller tumor sizes.
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Figure 5: Distribution of final best corrected visual acuity (BCVA) and status of foveal involvement and tumor area in the posterior pole according to the type of regression pattern. (A) Distribution of final best corrected visual acuity according to the type of regression pattern. Note that the eyes with type IV regression patterns tended to have better final BCVAs than did those of other regression types. (B) The distributions of foveal involvement and tumor size according to the type of the regression pattern. Note that the eyes with type IV regression patterns tended to have less frequent foveal involvements and smaller tumor sizes.

Mentions: Mean final BCVA was not significantly different according to type of regression. However, eyes with type IV regression patterns tended to have a better final BCVA compared to those of other types in the final BCVA distribution, as shown in Fig. 5A. According to the data presented in Fig. 5B, eyes with type IV regression patterns tended to have less frequent foveal involvement and smaller tumor area in the posterior pole.


Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Distribution of final best corrected visual acuity (BCVA) and status of foveal involvement and tumor area in the posterior pole according to the type of regression pattern. (A) Distribution of final best corrected visual acuity according to the type of regression pattern. Note that the eyes with type IV regression patterns tended to have better final BCVAs than did those of other regression types. (B) The distributions of foveal involvement and tumor size according to the type of the regression pattern. Note that the eyes with type IV regression patterns tended to have less frequent foveal involvements and smaller tumor sizes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992562&req=5

Figure 5: Distribution of final best corrected visual acuity (BCVA) and status of foveal involvement and tumor area in the posterior pole according to the type of regression pattern. (A) Distribution of final best corrected visual acuity according to the type of regression pattern. Note that the eyes with type IV regression patterns tended to have better final BCVAs than did those of other regression types. (B) The distributions of foveal involvement and tumor size according to the type of the regression pattern. Note that the eyes with type IV regression patterns tended to have less frequent foveal involvements and smaller tumor sizes.
Mentions: Mean final BCVA was not significantly different according to type of regression. However, eyes with type IV regression patterns tended to have a better final BCVA compared to those of other types in the final BCVA distribution, as shown in Fig. 5A. According to the data presented in Fig. 5B, eyes with type IV regression patterns tended to have less frequent foveal involvement and smaller tumor area in the posterior pole.

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

Show MeSH
Related in: MedlinePlus