Limits...
Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

Show MeSH

Related in: MedlinePlus

Distribution of final best corrected visual acuity (BCVA) according to tumor size. Group L (large) represents tumors greater than half of the size of posterior pole; group S (small) represents tumors less than half of the size of posterior pole. Note that only eyes with foveal involvement were included to avoid the influence of foveal involvement.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2992562&req=5

Figure 4: Distribution of final best corrected visual acuity (BCVA) according to tumor size. Group L (large) represents tumors greater than half of the size of posterior pole; group S (small) represents tumors less than half of the size of posterior pole. Note that only eyes with foveal involvement were included to avoid the influence of foveal involvement.

Mentions: Other probable prognostic factors were not significantly correlated with visual outcome. Mean final BCVA was better in group S (1 eye) than in group L (7 eyes), with averages of 20/25 and 20/1,262 (range, hand motion to 20/50), respectively. However, this result was not statistically significant due to the small number of cases in group S (p = 0.250). Two eyes (28.6%) in group L had an acuity of 20/200 or better, despite foveal involvement and large tumors in the posterior pole, as presented in Fig. 4.


Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Distribution of final best corrected visual acuity (BCVA) according to tumor size. Group L (large) represents tumors greater than half of the size of posterior pole; group S (small) represents tumors less than half of the size of posterior pole. Note that only eyes with foveal involvement were included to avoid the influence of foveal involvement.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992562&req=5

Figure 4: Distribution of final best corrected visual acuity (BCVA) according to tumor size. Group L (large) represents tumors greater than half of the size of posterior pole; group S (small) represents tumors less than half of the size of posterior pole. Note that only eyes with foveal involvement were included to avoid the influence of foveal involvement.
Mentions: Other probable prognostic factors were not significantly correlated with visual outcome. Mean final BCVA was better in group S (1 eye) than in group L (7 eyes), with averages of 20/25 and 20/1,262 (range, hand motion to 20/50), respectively. However, this result was not statistically significant due to the small number of cases in group S (p = 0.250). Two eyes (28.6%) in group L had an acuity of 20/200 or better, despite foveal involvement and large tumors in the posterior pole, as presented in Fig. 4.

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

Show MeSH
Related in: MedlinePlus