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Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

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Related in: MedlinePlus

Distribution of final best corrected visual acuity (BCVA) according to foveal involvement. Note that the final BCVAs were higher in cases of negative foveal involvement. Group F+ represents positive foveal involvement, and group F- represents negative foveal involvement.
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Figure 2: Distribution of final best corrected visual acuity (BCVA) according to foveal involvement. Note that the final BCVAs were higher in cases of negative foveal involvement. Group F+ represents positive foveal involvement, and group F- represents negative foveal involvement.

Mentions: All data regarding the probable risk factors and final BCVA are listed in Table 1. The only factor found to significantly correlate with visual outcome was the presence of foveal involvement. Mean final BCVA was significantly better in group F- (five eyes) than in group F+ (eight eyes), with averages of 20/26 (range, 20/50 to 20/16) in group F- and 20/778 (range, hand motion to 20/25) in group F+ (p = 0.006). All eyes in group F- had an acuity of 20/50 or better, whereas only four eyes (37.5%) in group F+ had an acuity of 20/200 or better, as shown in Fig. 2. The representative fundus photographs are presented according to the foveal involvement and visual outcome in Fig. 3.


Visual prognosis of retinoblastoma in the posterior pole treated with primary chemotherapy plus local treatments.

Kim JM, Kim JH, Kim SJ, Park KD, Shin HY, Ahn HS, Yu YS - Korean J Ophthalmol (2010)

Distribution of final best corrected visual acuity (BCVA) according to foveal involvement. Note that the final BCVAs were higher in cases of negative foveal involvement. Group F+ represents positive foveal involvement, and group F- represents negative foveal involvement.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992562&req=5

Figure 2: Distribution of final best corrected visual acuity (BCVA) according to foveal involvement. Note that the final BCVAs were higher in cases of negative foveal involvement. Group F+ represents positive foveal involvement, and group F- represents negative foveal involvement.
Mentions: All data regarding the probable risk factors and final BCVA are listed in Table 1. The only factor found to significantly correlate with visual outcome was the presence of foveal involvement. Mean final BCVA was significantly better in group F- (five eyes) than in group F+ (eight eyes), with averages of 20/26 (range, 20/50 to 20/16) in group F- and 20/778 (range, hand motion to 20/25) in group F+ (p = 0.006). All eyes in group F- had an acuity of 20/50 or better, whereas only four eyes (37.5%) in group F+ had an acuity of 20/200 or better, as shown in Fig. 2. The representative fundus photographs are presented according to the foveal involvement and visual outcome in Fig. 3.

Bottom Line: The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better.Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.Vision preservation should be considered when deciding on RBPP treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the visual outcomes of retinoblastoma in the posterior pole (RBPP) treated with chemotherapy plus local treatments and to address the prognostic factors that influence such outcomes.

Methods: The medical records of patients with RBPP diagnosed at the Department of Pediatric Ophthalmology, Seoul National University Children's Hospital between August 1987 and September 2007 were reviewed retrospectively. Only those patients treated via primary chemotherapy plus local treatments were included. The presence of foveal involvement and tumors in the posterior pole before and after treatment, the type of regression pattern and the best corrected visual acuity (BCVA) of each patient were evaluated.

Results: A total of 13 eyes in 12 patients were included. The mean final BCVA for treated RBPP was 20/210 (range, hand motion to 20/16). However, eight eyes (61.5%) had an acuity of 20/200 or better and seven eyes (53.8%) had an acuity of 20/50 or better. The mean final BCVA was significantly better in cases with negative foveal involvement; however, four eyes (37.5%) with positive foveal involvement had an acuity of 20/200 or better. Tumors area in the posterior pole and the type of regression pattern were not significantly related to final BCVA.

Conclusions: Over one half of the studied RBPP patients had working vision. Although the eyes had RBPP with positive foveal involvement, about one-third of the patients had working vision. Vision preservation should be considered when deciding on RBPP treatment.

Show MeSH
Related in: MedlinePlus