Limits...
Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.

Chen MJ, Jovanovic A, Taylor R - Diabetes Care (2010)

Bottom Line: There was a significant lower rise in plasma glucose on the snack day.The incremental area under the glucose curve was 450 ± 55 mmol · min/l on the snack day compared with 699 ± 99 mmol · min/l on the control day (P = 0.013).Consuming a high-protein prebreakfast snack results in almost 40% reduction of postprandial glucose increment.

View Article: PubMed Central - PubMed

Affiliation: Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

ABSTRACT

Objective: To evaluate the effect of a prebreakfast high-protein snack upon postbreakfast hyperglycemia.

Research design and methods: We studied 10 men and women with diet- and/or metformin-controlled type 2 diabetes. Metabolic changes after breakfast were compared between 2 days: breakfast taken only and soya-yogurt snack taken prior to breakfast.

Results: There was a significant lower rise in plasma glucose on the snack day. The incremental area under the glucose curve was 450 ± 55 mmol · min/l on the snack day compared with 699 ± 99 mmol · min/l on the control day (P = 0.013). The concentration of plasma free fatty acids immediately before breakfast correlated with the increment in plasma glucose (r = 0.50, P = 0.013).

Conclusions: Consuming a high-protein prebreakfast snack results in almost 40% reduction of postprandial glucose increment. The second-meal effect can be applied simply and practically to improve postbreakfast hyperglycemia in people with type 2 diabetes.

Show MeSH

Related in: MedlinePlus

Metabolic changes between the 2 study days in 10 subjects with type 2 diabetes. A: Plasma glucose concentrations. B: Incremental area under the plasma glucose curves during the 5-h postbreakfast period. C and D: Change in FFA and insulin concentrations, respectively. *P < 0.05; **P < 0.02; ***P < 0.01; □, snack day; ●, control day.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2992188&req=5

Figure 1: Metabolic changes between the 2 study days in 10 subjects with type 2 diabetes. A: Plasma glucose concentrations. B: Incremental area under the plasma glucose curves during the 5-h postbreakfast period. C and D: Change in FFA and insulin concentrations, respectively. *P < 0.05; **P < 0.02; ***P < 0.01; □, snack day; ●, control day.

Mentions: At baseline, 2 h before breakfast, fasting plasma glucose was similar on the 2 study days (6.6 ± 0.3 and 6.6 ± 0.4 mmol/l). The snack induced a small peak in plasma glucose at −60 min (7.3 ± 0.4 mmol/l). The concentrations of plasma glucose immediately before breakfast (t = 0 min) did not differ significantly between the 2 days (6.6 ± 0.3 vs. 6.4 ± 0.3 mmol/l, P = 0.45) (Fig. 1A).


Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.

Chen MJ, Jovanovic A, Taylor R - Diabetes Care (2010)

Metabolic changes between the 2 study days in 10 subjects with type 2 diabetes. A: Plasma glucose concentrations. B: Incremental area under the plasma glucose curves during the 5-h postbreakfast period. C and D: Change in FFA and insulin concentrations, respectively. *P < 0.05; **P < 0.02; ***P < 0.01; □, snack day; ●, control day.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992188&req=5

Figure 1: Metabolic changes between the 2 study days in 10 subjects with type 2 diabetes. A: Plasma glucose concentrations. B: Incremental area under the plasma glucose curves during the 5-h postbreakfast period. C and D: Change in FFA and insulin concentrations, respectively. *P < 0.05; **P < 0.02; ***P < 0.01; □, snack day; ●, control day.
Mentions: At baseline, 2 h before breakfast, fasting plasma glucose was similar on the 2 study days (6.6 ± 0.3 and 6.6 ± 0.4 mmol/l). The snack induced a small peak in plasma glucose at −60 min (7.3 ± 0.4 mmol/l). The concentrations of plasma glucose immediately before breakfast (t = 0 min) did not differ significantly between the 2 days (6.6 ± 0.3 vs. 6.4 ± 0.3 mmol/l, P = 0.45) (Fig. 1A).

Bottom Line: There was a significant lower rise in plasma glucose on the snack day.The incremental area under the glucose curve was 450 ± 55 mmol · min/l on the snack day compared with 699 ± 99 mmol · min/l on the control day (P = 0.013).Consuming a high-protein prebreakfast snack results in almost 40% reduction of postprandial glucose increment.

View Article: PubMed Central - PubMed

Affiliation: Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

ABSTRACT

Objective: To evaluate the effect of a prebreakfast high-protein snack upon postbreakfast hyperglycemia.

Research design and methods: We studied 10 men and women with diet- and/or metformin-controlled type 2 diabetes. Metabolic changes after breakfast were compared between 2 days: breakfast taken only and soya-yogurt snack taken prior to breakfast.

Results: There was a significant lower rise in plasma glucose on the snack day. The incremental area under the glucose curve was 450 ± 55 mmol · min/l on the snack day compared with 699 ± 99 mmol · min/l on the control day (P = 0.013). The concentration of plasma free fatty acids immediately before breakfast correlated with the increment in plasma glucose (r = 0.50, P = 0.013).

Conclusions: Consuming a high-protein prebreakfast snack results in almost 40% reduction of postprandial glucose increment. The second-meal effect can be applied simply and practically to improve postbreakfast hyperglycemia in people with type 2 diabetes.

Show MeSH
Related in: MedlinePlus