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Sebaceous gland carcinoma of the eyelid.

Wali UK, Al-Mujaini A - Oman J Ophthalmol (2010)

Bottom Line: Sebaceous gland carcinoma, commonly arises in the periocular area, is an uncommon condition.It represents 1-5.5% of eyelid malignancies and is considered to be the third most common eyelid malignancy after basal cell and squamous cell carcinomas, although few reports placed this tumor as second most common after basal cell carcinoma.It usually affects elderly women and characterized by high rate of local recurrence, regional, and distant metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine and Health Science, Sultan Qaboos University, Muscat, Sultanate Oman.

ABSTRACT
Sebaceous gland carcinoma, commonly arises in the periocular area, is an uncommon condition. It represents 1-5.5% of eyelid malignancies and is considered to be the third most common eyelid malignancy after basal cell and squamous cell carcinomas, although few reports placed this tumor as second most common after basal cell carcinoma. It usually affects elderly women and characterized by high rate of local recurrence, regional, and distant metastases. A delay in diagnosis, which can be attributed primarily to ability of this tumor to masquerade as more benign conditions, often leads to inappropriate management with increased morbidity and mortality rates. In this study, the authors discuss key elements of the primary disease and therapeutic options available to treat such devastating problem.

No MeSH data available.


Related in: MedlinePlus

Malignant cells with vaculated cytoplasm (V), mitotic figures (M), and areas of necrosis (N) (H & E, ×60)
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Figure 0001: Malignant cells with vaculated cytoplasm (V), mitotic figures (M), and areas of necrosis (N) (H & E, ×60)

Mentions: Immunohistopathology shows that the cells occur in irregular lobular masses with distinctive invasiveness. The cytoplasm is pale, foamy, and vacuolated [Figure 1]. This feature of foamy cytoplasm is seen only in sebaceous carcinoma. The nuclei are hyperchromatic, and the cells stain positive for lipid such as oil red O stain. The ultrastructural features of SGC include desmosoes, tonofilaments, and intracytoplasmic nonmembrane bound lipid. Occasionally bizarre and atypical tripolar mitotic cells may be seen. Immunohistochemical reaction aids in the diagnosis of SGC. Molecular biology of SGC suggests dysplasia if there is no expression of p53 or invasiveness, if there is hyperexpression of p53.


Sebaceous gland carcinoma of the eyelid.

Wali UK, Al-Mujaini A - Oman J Ophthalmol (2010)

Malignant cells with vaculated cytoplasm (V), mitotic figures (M), and areas of necrosis (N) (H & E, ×60)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2992157&req=5

Figure 0001: Malignant cells with vaculated cytoplasm (V), mitotic figures (M), and areas of necrosis (N) (H & E, ×60)
Mentions: Immunohistopathology shows that the cells occur in irregular lobular masses with distinctive invasiveness. The cytoplasm is pale, foamy, and vacuolated [Figure 1]. This feature of foamy cytoplasm is seen only in sebaceous carcinoma. The nuclei are hyperchromatic, and the cells stain positive for lipid such as oil red O stain. The ultrastructural features of SGC include desmosoes, tonofilaments, and intracytoplasmic nonmembrane bound lipid. Occasionally bizarre and atypical tripolar mitotic cells may be seen. Immunohistochemical reaction aids in the diagnosis of SGC. Molecular biology of SGC suggests dysplasia if there is no expression of p53 or invasiveness, if there is hyperexpression of p53.

Bottom Line: Sebaceous gland carcinoma, commonly arises in the periocular area, is an uncommon condition.It represents 1-5.5% of eyelid malignancies and is considered to be the third most common eyelid malignancy after basal cell and squamous cell carcinomas, although few reports placed this tumor as second most common after basal cell carcinoma.It usually affects elderly women and characterized by high rate of local recurrence, regional, and distant metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, College of Medicine and Health Science, Sultan Qaboos University, Muscat, Sultanate Oman.

ABSTRACT
Sebaceous gland carcinoma, commonly arises in the periocular area, is an uncommon condition. It represents 1-5.5% of eyelid malignancies and is considered to be the third most common eyelid malignancy after basal cell and squamous cell carcinomas, although few reports placed this tumor as second most common after basal cell carcinoma. It usually affects elderly women and characterized by high rate of local recurrence, regional, and distant metastases. A delay in diagnosis, which can be attributed primarily to ability of this tumor to masquerade as more benign conditions, often leads to inappropriate management with increased morbidity and mortality rates. In this study, the authors discuss key elements of the primary disease and therapeutic options available to treat such devastating problem.

No MeSH data available.


Related in: MedlinePlus