Limits...
Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report.

Wilenius J, Mäkelä JP, Lyytinen J, Paetau A, Palomäki M, Pekkonen E - Case Rep Neurol (2010)

Bottom Line: Post-mortem examination confirmed sporadic CJD.The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI.Sources of AEFs were found in both temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: BioMag Laboratory, HUSLAB, Helsinki, Finland.

ABSTRACT
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized with a beamformer software. Sources of sharp transients and AEFs were modeled with equivalent current dipoles. The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI. Sources of AEFs were found in both temporal lobes. Magnetoencephalography measurements on CJD patients are feasible, and provide efficient means for localizing abnormal cortical activity in CJD.

No MeSH data available.


Related in: MedlinePlus

a A ten-second segment of MEG signal from selected temporal sensors over both hemispheres. A FIRDA run starts during the last four seconds of the recording. A sharp transient is marked by the black rectangle. b Beamformer source estimation. The maximal activity is localized in the left frontotemporal area. c ECD locations of sharp transients are also most concentrated on the left frontotemporal area.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC2992031&req=5

Figure 2: a A ten-second segment of MEG signal from selected temporal sensors over both hemispheres. A FIRDA run starts during the last four seconds of the recording. A sharp transient is marked by the black rectangle. b Beamformer source estimation. The maximal activity is localized in the left frontotemporal area. c ECD locations of sharp transients are also most concentrated on the left frontotemporal area.

Mentions: MEG showed abnormal delta and low theta band activity in both hemispheres. FIRDA-like intermittent runs of high amplitude slow wave activity were observed as well. No clear PSWCs were present. However, frequent sharp transients were observed. All of these signals were most pronounced in the left hemisphere (fig. 2a).


Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report.

Wilenius J, Mäkelä JP, Lyytinen J, Paetau A, Palomäki M, Pekkonen E - Case Rep Neurol (2010)

a A ten-second segment of MEG signal from selected temporal sensors over both hemispheres. A FIRDA run starts during the last four seconds of the recording. A sharp transient is marked by the black rectangle. b Beamformer source estimation. The maximal activity is localized in the left frontotemporal area. c ECD locations of sharp transients are also most concentrated on the left frontotemporal area.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2992031&req=5

Figure 2: a A ten-second segment of MEG signal from selected temporal sensors over both hemispheres. A FIRDA run starts during the last four seconds of the recording. A sharp transient is marked by the black rectangle. b Beamformer source estimation. The maximal activity is localized in the left frontotemporal area. c ECD locations of sharp transients are also most concentrated on the left frontotemporal area.
Mentions: MEG showed abnormal delta and low theta band activity in both hemispheres. FIRDA-like intermittent runs of high amplitude slow wave activity were observed as well. No clear PSWCs were present. However, frequent sharp transients were observed. All of these signals were most pronounced in the left hemisphere (fig. 2a).

Bottom Line: Post-mortem examination confirmed sporadic CJD.The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI.Sources of AEFs were found in both temporal lobes.

View Article: PubMed Central - PubMed

Affiliation: BioMag Laboratory, HUSLAB, Helsinki, Finland.

ABSTRACT
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized with a beamformer software. Sources of sharp transients and AEFs were modeled with equivalent current dipoles. The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI. Sources of AEFs were found in both temporal lobes. Magnetoencephalography measurements on CJD patients are feasible, and provide efficient means for localizing abnormal cortical activity in CJD.

No MeSH data available.


Related in: MedlinePlus