Prediction of ESRD and death among people with CKD: the Chronic Renal Impairment in Birmingham (CRIB) prospective cohort study.
Bottom Line: For death, age, N-terminal pro-brain natriuretic peptide, troponin T level, and cigarette smoking remained strongly predictive of risk.Other important factors may have been missed because of limited study power.Larger cohort studies are required to further validate these results.
Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. firstname.lastname@example.orgShow MeSH
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Mentions: There were strong inverse log-linear associations between proportional differences in eGFR and risks of ESRD and death (Fig 2). This was much more marked for ESRD than for death. Within the range of eGFRs studied, each 30% lower baseline eGFR (eg, 40 vs 28 mL/min/1.73 m2) was associated with an approximately 3-fold increase in risk of ESRD (RR, 3.02; 95% CI, 2.65-3.43; P < 0.001) and a 1.3-fold increase in risk of death (RR, 1.30; 95% CI, 1.17-1.45; P < 0.001). In this cohort, the risk of dying during follow-up exceeded that of developing ESRD for those with eGFR >25 mL/min/1.73 m2 (Fig 2).
Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. email@example.com