Prediction of ESRD and death among people with CKD: the Chronic Renal Impairment in Birmingham (CRIB) prospective cohort study.
Bottom Line: For death, age, N-terminal pro-brain natriuretic peptide, troponin T level, and cigarette smoking remained strongly predictive of risk.Other important factors may have been missed because of limited study power.Larger cohort studies are required to further validate these results.
Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. email@example.comShow MeSH
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Mentions: During a mean of 4.1 years' (1,571 person-years) follow-up for renal events, 190 participants reached ESRD (mean rate, 12.1% per annum [pa]; Table 3). In participants initially at CKD stages 3, 4, and 5, annual event rates of ESRD were 1.6%, 9.6%, and 58.2%, respectively (between-group comparison, P < 0.001; Fig 1). No patients with stage 3 CKD at baseline required dialysis or transplant within the first 4 years of follow-up. In those with stage 4 CKD initially, median time to ESRD was about 5 years longer than for those with stage 5 CKD (∼6 vs 1 year, respectively; Fig 1).
Affiliation: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. firstname.lastname@example.org