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Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials.

Venugopal V, Laing CM, Ludman A, Yellon DM, Hausenloy D - Am. J. Kidney Dis. (2010)

Bottom Line: Novel treatment strategies are required to reduce the development of acute kidney injury (AKI) in patients undergoing cardiac surgery.Numbers of participants with AKI stages 1, 2, and 3 were 1 (3%), 3 (8%), and 0 in the intervention group compared with 10 (25%), 0, and 0 in the control group, respectively (P = 0.005).The decrease in AKI was independent of the effect of concomitant aortic valve replacement and cross-clamp times, which were distributed unevenly between the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, University College London Hospital, London, UK. v.venugopal@ucl.ac.uk

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Related in: MedlinePlus

Graph shows trends in serum creatinine levels in the 2 groups at baseline and during 72 hours postoperatively. There was no significant difference between the 2 groups using analysis of variance with repeated measures. Note: Conversion factor for creatinine in mg/dL to μmol/L, ×88.4. Abbreviation: RIPC, remote ischemic preconditioning.
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fig2: Graph shows trends in serum creatinine levels in the 2 groups at baseline and during 72 hours postoperatively. There was no significant difference between the 2 groups using analysis of variance with repeated measures. Note: Conversion factor for creatinine in mg/dL to μmol/L, ×88.4. Abbreviation: RIPC, remote ischemic preconditioning.

Mentions: AKI was diagnosed using creatinine criteria in 10 of the 14 patients; in 1 case on day 1 and 9 cases on day 2 postoperatively. The creatinine level increase in these patients persisted for 48 hours. All these patients also had a decrease in urine output. All 14 patients with AKI fulfilled urine volume criteria (7 on day 1 and 7 on day 2 postoperatively), 10 of whom also had increases in serum creatinine levels persisting over 48 hours (AKI diagnosed and staged according to both criteria). Four patients who fulfilled urine volume criteria did not have a creatinine level increase during this period. Baseline and postoperative serum creatinine levels are shown in Fig 2. AKI was diagnosed on day 1 in 4 patients, on day 2 in 8 patients, and on day 3 in 2 patients.


Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials.

Venugopal V, Laing CM, Ludman A, Yellon DM, Hausenloy D - Am. J. Kidney Dis. (2010)

Graph shows trends in serum creatinine levels in the 2 groups at baseline and during 72 hours postoperatively. There was no significant difference between the 2 groups using analysis of variance with repeated measures. Note: Conversion factor for creatinine in mg/dL to μmol/L, ×88.4. Abbreviation: RIPC, remote ischemic preconditioning.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991586&req=5

fig2: Graph shows trends in serum creatinine levels in the 2 groups at baseline and during 72 hours postoperatively. There was no significant difference between the 2 groups using analysis of variance with repeated measures. Note: Conversion factor for creatinine in mg/dL to μmol/L, ×88.4. Abbreviation: RIPC, remote ischemic preconditioning.
Mentions: AKI was diagnosed using creatinine criteria in 10 of the 14 patients; in 1 case on day 1 and 9 cases on day 2 postoperatively. The creatinine level increase in these patients persisted for 48 hours. All these patients also had a decrease in urine output. All 14 patients with AKI fulfilled urine volume criteria (7 on day 1 and 7 on day 2 postoperatively), 10 of whom also had increases in serum creatinine levels persisting over 48 hours (AKI diagnosed and staged according to both criteria). Four patients who fulfilled urine volume criteria did not have a creatinine level increase during this period. Baseline and postoperative serum creatinine levels are shown in Fig 2. AKI was diagnosed on day 1 in 4 patients, on day 2 in 8 patients, and on day 3 in 2 patients.

Bottom Line: Novel treatment strategies are required to reduce the development of acute kidney injury (AKI) in patients undergoing cardiac surgery.Numbers of participants with AKI stages 1, 2, and 3 were 1 (3%), 3 (8%), and 0 in the intervention group compared with 10 (25%), 0, and 0 in the control group, respectively (P = 0.005).The decrease in AKI was independent of the effect of concomitant aortic valve replacement and cross-clamp times, which were distributed unevenly between the 2 groups.

View Article: PubMed Central - PubMed

Affiliation: The Hatter Cardiovascular Institute, University College London Hospital, London, UK. v.venugopal@ucl.ac.uk

Show MeSH
Related in: MedlinePlus