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Prediction of perineural invasion and its prognostic value in patients with prostate cancer.

Lee JT, Lee S, Yun CJ, Jeon BJ, Kim JM, Ha HK, Lee W, Chung MK - Korean J Urol (2010)

Bottom Line: We also researched preoperative factors that were associated with perineural invasion.In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019).However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Busan Saint Mary's Medical Center, Busan, Korea.

ABSTRACT

Purpose: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer.

Materials and methods: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion.

Results: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p=0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726).

Conclusions: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus

Cumulative biochemical recurrence rate according to perineural invasion in a prostatectomy specimen (PNIp). The 5-year biochemical recurrence rate with and without PNIp was 0.808 and 0.850, respectively.
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Figure 2: Cumulative biochemical recurrence rate according to perineural invasion in a prostatectomy specimen (PNIp). The 5-year biochemical recurrence rate with and without PNIp was 0.808 and 0.850, respectively.

Mentions: The relations between PNIp and other clinical and pathological parameters were investigated with the Pearson correlation. Age (p=0.022), primary Gleason grade (p<0.001), Gleason score (p<0.001), tumor stage (p<0.001), tumor volume of the prostate (p<0.001), lymphovascular invasion (p<0.001), PNIp (p=0.018), surgical margin status (p=0.018), number of positive lymph nodes (p=0.004), nadir PSA (p<0.001), the first PSA after surgery (p=0.041), PSA at 1 year after surgery (p<0.001), and PSA velocity (p=0.049) were significantly related to biochemical serum PSA recurrence. Using the log-rank test, we found no significant difference in biochemical serum PSA recurrence between patients with PNIp and those without PNIp (p=0.597; Fig. 2). In a multivariate analysis, nadir PSA (p<0.001, hazard ratio=61.746, 95% CI: 15.363-248.174) and PSA at 1 year after surgery (p<0.001, hazard ratio=2.878, 95% CI: 1.893-4.375) were significantly related to biochemical serum PSA recurrence. However, PNIp was not correlated with biochemical recurrence (p=0.364).


Prediction of perineural invasion and its prognostic value in patients with prostate cancer.

Lee JT, Lee S, Yun CJ, Jeon BJ, Kim JM, Ha HK, Lee W, Chung MK - Korean J Urol (2010)

Cumulative biochemical recurrence rate according to perineural invasion in a prostatectomy specimen (PNIp). The 5-year biochemical recurrence rate with and without PNIp was 0.808 and 0.850, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2991570&req=5

Figure 2: Cumulative biochemical recurrence rate according to perineural invasion in a prostatectomy specimen (PNIp). The 5-year biochemical recurrence rate with and without PNIp was 0.808 and 0.850, respectively.
Mentions: The relations between PNIp and other clinical and pathological parameters were investigated with the Pearson correlation. Age (p=0.022), primary Gleason grade (p<0.001), Gleason score (p<0.001), tumor stage (p<0.001), tumor volume of the prostate (p<0.001), lymphovascular invasion (p<0.001), PNIp (p=0.018), surgical margin status (p=0.018), number of positive lymph nodes (p=0.004), nadir PSA (p<0.001), the first PSA after surgery (p=0.041), PSA at 1 year after surgery (p<0.001), and PSA velocity (p=0.049) were significantly related to biochemical serum PSA recurrence. Using the log-rank test, we found no significant difference in biochemical serum PSA recurrence between patients with PNIp and those without PNIp (p=0.597; Fig. 2). In a multivariate analysis, nadir PSA (p<0.001, hazard ratio=61.746, 95% CI: 15.363-248.174) and PSA at 1 year after surgery (p<0.001, hazard ratio=2.878, 95% CI: 1.893-4.375) were significantly related to biochemical serum PSA recurrence. However, PNIp was not correlated with biochemical recurrence (p=0.364).

Bottom Line: We also researched preoperative factors that were associated with perineural invasion.In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019).However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Busan Saint Mary's Medical Center, Busan, Korea.

ABSTRACT

Purpose: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer.

Materials and methods: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion.

Results: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p=0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726).

Conclusions: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus