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Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.

Al Baghli A, Reddy SS, Reddy MA - Middle East Afr J Ophthalmol (2010)

Bottom Line: We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid.The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

View Article: PubMed Central - PubMed

Affiliation: Department Oculoplastic Surgery, Al-Bahar Eye Centre, Ibn Sina Hospital, Safat, Kuwait.

ABSTRACT
We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid. The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern. Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

No MeSH data available.


Related in: MedlinePlus

Tumor cells with predominant polyhedral cell-type and few clear cell-type cells (H and E, × 400)
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Figure 0003: Tumor cells with predominant polyhedral cell-type and few clear cell-type cells (H and E, × 400)

Mentions: Histopathologic examination revealed a tumor in the dermis with surrounding fibrous capsule. Two types of tumor cells were noted with predominance of one cell-type which was polyhedral to round in configuration with round to oval nuclei and prominent nucleoli surrounded by faintly basophilic cytoplasm. The second cell-type was clear, round to oval with eccentric nucleus. The tumor cells were arranged in lobules and separated by delicate fibrous collagenous tissue [Figure 3]. The lobules were lined by cuboidal or columnar cells with few cystic spaces, brisk mitotic figures with surface ulceration, and infiltrating margins. No areas of necrosis were noticed. The tumor cells exhibited an intracytoplasmic substance that stained positively with periodic acid-Schiff stain and were diastase-sensitive. There was positive immunohistochemical reactivity to epithelial membrane antigen. A diagnosis of malignant nodular hidradenoma was performed on the basis of the histopathologic and immunohistochemical studies [Figure 4].


Malignant nodular hidradenoma of the eyelid: a rare sweat gland tumor.

Al Baghli A, Reddy SS, Reddy MA - Middle East Afr J Ophthalmol (2010)

Tumor cells with predominant polyhedral cell-type and few clear cell-type cells (H and E, × 400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991459&req=5

Figure 0003: Tumor cells with predominant polyhedral cell-type and few clear cell-type cells (H and E, × 400)
Mentions: Histopathologic examination revealed a tumor in the dermis with surrounding fibrous capsule. Two types of tumor cells were noted with predominance of one cell-type which was polyhedral to round in configuration with round to oval nuclei and prominent nucleoli surrounded by faintly basophilic cytoplasm. The second cell-type was clear, round to oval with eccentric nucleus. The tumor cells were arranged in lobules and separated by delicate fibrous collagenous tissue [Figure 3]. The lobules were lined by cuboidal or columnar cells with few cystic spaces, brisk mitotic figures with surface ulceration, and infiltrating margins. No areas of necrosis were noticed. The tumor cells exhibited an intracytoplasmic substance that stained positively with periodic acid-Schiff stain and were diastase-sensitive. There was positive immunohistochemical reactivity to epithelial membrane antigen. A diagnosis of malignant nodular hidradenoma was performed on the basis of the histopathologic and immunohistochemical studies [Figure 4].

Bottom Line: We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid.The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern.Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

View Article: PubMed Central - PubMed

Affiliation: Department Oculoplastic Surgery, Al-Bahar Eye Centre, Ibn Sina Hospital, Safat, Kuwait.

ABSTRACT
We report a case of malignant nodular hidradenoma in a middle-aged man, who presented with a nodular swelling in the eyelid. The tumor was similar to its benign counterpart but had additional features such as surface ulceration, numerous mitiotic figures, and an infiltrative growth pattern. Malignant forms of hidradenomas are unusual and the possibility this variant should be considered in the differential diagnosis of eyelid tumors.

No MeSH data available.


Related in: MedlinePlus