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Corneal Crosslinking for Keratoconus in Iranian Patients: Outcomes at 1 year following treatment.

Saffarian L, Khakshoor H, Zarei-Ghanavati M, Esmaily H - Middle East Afr J Ophthalmol (2010)

Bottom Line: P < 0.05 was statistically significant.UCVA and BSCVA were statistically higher postoperatively (P < 0.001, both parameters).The mean astigmatism decreased by 0.78 ± 1.49 diopter (D) with significant variation during the follow-up period (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Islamic Azad University of Mashhad, Mashhad, Iran.

ABSTRACT

Aim and design: A retrospective, nonrandomized, single-center clinical study was designed to evaluate the outcomes of corneal collagen crosslinking (CXL) for progressive keratoconus in Iranian patients 12 months after CXL.

Settings: This study was carried out at Navid Didegan Eye Center, a private clinic, Mashhad, Iran.

Materials and methods: Ninety-two eyes of 53 subjects with progressive keratoconus were evaluated in this study. All eyes completed 1-year follow-up. The outcome measures were uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), sphere and cylinder refraction, keratometry, and corneal thickness. Comparison of baseline and 1-year postoperative data is reported in this study. The Wilcoxon signed-ranked and Student's t-tests were used for statistical analyses. P < 0.05 was statistically significant.

Results: The mean age was 21.5 ± 3.4 years (range, 16 -30 years). Thirty-one (58.5%) of the subjects were men and 22 (41.5%) were women. Mean baseline UCVA and BSCVA were 0.61 ± 0.31 and 0.06 ± 0.12 logarithm of minimal angle of resolution (logMAR), respectively. One year postoperatively UCVA was 0.31 ± 0.25 logMAR and BSCVA was 0.0 ± 0.01 logMAR. UCVA and BSCVA were statistically higher postoperatively (P < 0.001, both parameters). The mean astigmatism decreased by 0.78 ± 1.49 diopter (D) with significant variation during the follow-up period (P < 0.001). Mean baseline simulated keratometry (SIM K) was 46.94 ± 2.37 D and decreased to 46.0 ± 2.33 D on year postoperatively (P < 0.001).

Conclusion: Corneal CXL seems to be efficient in stabilization of progressive keratoconus progression in Iranian patients at 1 year of followup.

No MeSH data available.


Related in: MedlinePlus

Change in uncorrected visual acuity (UCVA) 12 months after corneal crosslinking with riboflavin for progressive keratoconus
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Figure 0001: Change in uncorrected visual acuity (UCVA) 12 months after corneal crosslinking with riboflavin for progressive keratoconus

Mentions: The improvement in UCVA was observed in 88.2% of eyes. Fifty eyes (54.3%) gained three or more lines of UCVA and two eyes (2.1%) lost two lines. The mean UCVA significantly improved 12 months after surgery from 0.61 ± 0.31 logMAR to 0.31 ± 0.25 logMAR (P < 0.001) [Figure 1]. The mean BSCVA increased significantly from 0.06 ± 0.12 preoperatively to 0.0 ± 0.01 logMAR postoperatively and after 1 year (P < 0.001). Eight eyes (8.6%) gained three or more lines of BSCVA.


Corneal Crosslinking for Keratoconus in Iranian Patients: Outcomes at 1 year following treatment.

Saffarian L, Khakshoor H, Zarei-Ghanavati M, Esmaily H - Middle East Afr J Ophthalmol (2010)

Change in uncorrected visual acuity (UCVA) 12 months after corneal crosslinking with riboflavin for progressive keratoconus
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991457&req=5

Figure 0001: Change in uncorrected visual acuity (UCVA) 12 months after corneal crosslinking with riboflavin for progressive keratoconus
Mentions: The improvement in UCVA was observed in 88.2% of eyes. Fifty eyes (54.3%) gained three or more lines of UCVA and two eyes (2.1%) lost two lines. The mean UCVA significantly improved 12 months after surgery from 0.61 ± 0.31 logMAR to 0.31 ± 0.25 logMAR (P < 0.001) [Figure 1]. The mean BSCVA increased significantly from 0.06 ± 0.12 preoperatively to 0.0 ± 0.01 logMAR postoperatively and after 1 year (P < 0.001). Eight eyes (8.6%) gained three or more lines of BSCVA.

Bottom Line: P < 0.05 was statistically significant.UCVA and BSCVA were statistically higher postoperatively (P < 0.001, both parameters).The mean astigmatism decreased by 0.78 ± 1.49 diopter (D) with significant variation during the follow-up period (P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Islamic Azad University of Mashhad, Mashhad, Iran.

ABSTRACT

Aim and design: A retrospective, nonrandomized, single-center clinical study was designed to evaluate the outcomes of corneal collagen crosslinking (CXL) for progressive keratoconus in Iranian patients 12 months after CXL.

Settings: This study was carried out at Navid Didegan Eye Center, a private clinic, Mashhad, Iran.

Materials and methods: Ninety-two eyes of 53 subjects with progressive keratoconus were evaluated in this study. All eyes completed 1-year follow-up. The outcome measures were uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), sphere and cylinder refraction, keratometry, and corneal thickness. Comparison of baseline and 1-year postoperative data is reported in this study. The Wilcoxon signed-ranked and Student's t-tests were used for statistical analyses. P < 0.05 was statistically significant.

Results: The mean age was 21.5 ± 3.4 years (range, 16 -30 years). Thirty-one (58.5%) of the subjects were men and 22 (41.5%) were women. Mean baseline UCVA and BSCVA were 0.61 ± 0.31 and 0.06 ± 0.12 logarithm of minimal angle of resolution (logMAR), respectively. One year postoperatively UCVA was 0.31 ± 0.25 logMAR and BSCVA was 0.0 ± 0.01 logMAR. UCVA and BSCVA were statistically higher postoperatively (P < 0.001, both parameters). The mean astigmatism decreased by 0.78 ± 1.49 diopter (D) with significant variation during the follow-up period (P < 0.001). Mean baseline simulated keratometry (SIM K) was 46.94 ± 2.37 D and decreased to 46.0 ± 2.33 D on year postoperatively (P < 0.001).

Conclusion: Corneal CXL seems to be efficient in stabilization of progressive keratoconus progression in Iranian patients at 1 year of followup.

No MeSH data available.


Related in: MedlinePlus