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Spatial temperature distribution in human hairy and glabrous skin after infrared CO2 laser radiation.

Frahm KS, Andersen OK, Arendt-Nielsen L, Mørch CD - Biomed Eng Online (2010)

Bottom Line: The laser energy is absorbed by the water content in the most superficial layers of the skin.The simulations were compared to the subjective pain intensity ratings from 16 subjects and to the surface skin temperature distributions measured by an infrared camera.The model simulations of superficial temperature correlated with the measured skin surface temperature (r > 0.90, p < 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers vej 7D-3, DK 9220 Aalborg, Denmark. ksf@hst.aau.dk

ABSTRACT

Background: CO2 lasers have been used for several decades as an experimental non-touching pain stimulator. The laser energy is absorbed by the water content in the most superficial layers of the skin. The deeper located nociceptors are activated by passive conduction of heat from superficial to deeper skin layers.

Methods: In the current study, a 2D axial finite element model was developed and validated to describe the spatial temperature distribution in the skin after infrared CO2 laser stimulation. The geometry of the model was based on high resolution ultrasound scans. The simulations were compared to the subjective pain intensity ratings from 16 subjects and to the surface skin temperature distributions measured by an infrared camera.

Results: The stimulations were sensed significantly slower and less intense in glabrous skin than they were in hairy skin (MANOVA, p < 0.001). The model simulations of superficial temperature correlated with the measured skin surface temperature (r > 0.90, p < 0.001). Of the 16 subjects tested; eight subjects reported pricking pain in the hairy skin following a stimulus of 0.6 J/cm2 (5 W, 0.12 s, d1/e2 = 11.4 mm) only two reported pain to glabrous skin stimulation using the same stimulus intensity. The temperature at the epidermal-dermal junction (depth 50 μm in hairy and depth 133 μm in glabrous skin) was estimated to 46°C for hairy skin stimulation and 39°C for glabrous skin stimulation.

Conclusions: As compared to previous one dimensional heat distribution models, the current two dimensional model provides new possibilities for detailed studies regarding CO2 laser stimulation intensity, temperature levels and nociceptor activation.

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Related in: MedlinePlus

The figure illustrates a linear regression analysis between the reported perception and the temperature profiles at varying depths. Due to high fluctuations of the raw psychophysical data (VAS) a lowpass filter was applied for removing measuring artifacts (moving average filter, 5 points span inducing no time lag). For hairy skin the highest correlation was found at approximately 50 μm and for the glabrous skin the highest correlation was found at approximately 130 μm.
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Figure 9: The figure illustrates a linear regression analysis between the reported perception and the temperature profiles at varying depths. Due to high fluctuations of the raw psychophysical data (VAS) a lowpass filter was applied for removing measuring artifacts (moving average filter, 5 points span inducing no time lag). For hairy skin the highest correlation was found at approximately 50 μm and for the glabrous skin the highest correlation was found at approximately 130 μm.

Mentions: In hairy skin the strongest correlation between VAS and subsurface temperature was found for the temperature profile at 50 μm and with only one distinct peak (Figure 9). For glabrous skin, two peaks in the correlation coefficients were found; one at 50 μm but the strongest correlation was detected at 130 μm. These correlations might indicate the most likely receptor depth in hairy and glabrous skin.


Spatial temperature distribution in human hairy and glabrous skin after infrared CO2 laser radiation.

Frahm KS, Andersen OK, Arendt-Nielsen L, Mørch CD - Biomed Eng Online (2010)

The figure illustrates a linear regression analysis between the reported perception and the temperature profiles at varying depths. Due to high fluctuations of the raw psychophysical data (VAS) a lowpass filter was applied for removing measuring artifacts (moving average filter, 5 points span inducing no time lag). For hairy skin the highest correlation was found at approximately 50 μm and for the glabrous skin the highest correlation was found at approximately 130 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991325&req=5

Figure 9: The figure illustrates a linear regression analysis between the reported perception and the temperature profiles at varying depths. Due to high fluctuations of the raw psychophysical data (VAS) a lowpass filter was applied for removing measuring artifacts (moving average filter, 5 points span inducing no time lag). For hairy skin the highest correlation was found at approximately 50 μm and for the glabrous skin the highest correlation was found at approximately 130 μm.
Mentions: In hairy skin the strongest correlation between VAS and subsurface temperature was found for the temperature profile at 50 μm and with only one distinct peak (Figure 9). For glabrous skin, two peaks in the correlation coefficients were found; one at 50 μm but the strongest correlation was detected at 130 μm. These correlations might indicate the most likely receptor depth in hairy and glabrous skin.

Bottom Line: The laser energy is absorbed by the water content in the most superficial layers of the skin.The simulations were compared to the subjective pain intensity ratings from 16 subjects and to the surface skin temperature distributions measured by an infrared camera.The model simulations of superficial temperature correlated with the measured skin surface temperature (r > 0.90, p < 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers vej 7D-3, DK 9220 Aalborg, Denmark. ksf@hst.aau.dk

ABSTRACT

Background: CO2 lasers have been used for several decades as an experimental non-touching pain stimulator. The laser energy is absorbed by the water content in the most superficial layers of the skin. The deeper located nociceptors are activated by passive conduction of heat from superficial to deeper skin layers.

Methods: In the current study, a 2D axial finite element model was developed and validated to describe the spatial temperature distribution in the skin after infrared CO2 laser stimulation. The geometry of the model was based on high resolution ultrasound scans. The simulations were compared to the subjective pain intensity ratings from 16 subjects and to the surface skin temperature distributions measured by an infrared camera.

Results: The stimulations were sensed significantly slower and less intense in glabrous skin than they were in hairy skin (MANOVA, p < 0.001). The model simulations of superficial temperature correlated with the measured skin surface temperature (r > 0.90, p < 0.001). Of the 16 subjects tested; eight subjects reported pricking pain in the hairy skin following a stimulus of 0.6 J/cm2 (5 W, 0.12 s, d1/e2 = 11.4 mm) only two reported pain to glabrous skin stimulation using the same stimulus intensity. The temperature at the epidermal-dermal junction (depth 50 μm in hairy and depth 133 μm in glabrous skin) was estimated to 46°C for hairy skin stimulation and 39°C for glabrous skin stimulation.

Conclusions: As compared to previous one dimensional heat distribution models, the current two dimensional model provides new possibilities for detailed studies regarding CO2 laser stimulation intensity, temperature levels and nociceptor activation.

Show MeSH
Related in: MedlinePlus