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Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.

Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, Hashimoto K, Iyo M - Ann Gen Psychiatry (2010)

Bottom Line: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude.Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate.The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan. fukami@faculty.chiba-u.jp.

ABSTRACT

Background: Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects.

Methods: Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically (14 days). The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test, trail making test, digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning.

Results: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore, subchronic administration of etizolam, but not ethyl loflazepate, still caused a weak prolongation in P300 latency. In contrast, neuropsychological tests showed no difference.

Conclusions: The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

No MeSH data available.


Related in: MedlinePlus

Effects of acute and subchronic treatment with etizolam and ethyl loflazepate on neuropsychological tests.
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Figure 3: Effects of acute and subchronic treatment with etizolam and ethyl loflazepate on neuropsychological tests.

Mentions: For acute effects of drug treatment on neuropsychological tests, two-way repeated ANOVA showed significant practice effects of repeated testing, but not effects of drug group, on test scoring without a significant interaction in some tests including trail making A (F (1,16) = 7.399, P = 0.0151, Figure 3a), trail making B (F (1,16) = 8.409, P = 0.0104, Figure 3b), digit span forward (F (1,16) = 8.696, P = 0.0094, Figure 3c), verbal paired associates immediate memory (F(1,16) = 6.485, P = 0.0215, Figure 3e) and digit symbol (F(1,16) = 24.209, P = 0.0002, Figure 3g), and no significant effects of repeated testing and drugs on test scoring without a significant interaction in other tests such as digit span backward (Figure 3d) and verbal paired associates delayed recall (Figure 3f).


Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.

Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, Hashimoto K, Iyo M - Ann Gen Psychiatry (2010)

Effects of acute and subchronic treatment with etizolam and ethyl loflazepate on neuropsychological tests.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991318&req=5

Figure 3: Effects of acute and subchronic treatment with etizolam and ethyl loflazepate on neuropsychological tests.
Mentions: For acute effects of drug treatment on neuropsychological tests, two-way repeated ANOVA showed significant practice effects of repeated testing, but not effects of drug group, on test scoring without a significant interaction in some tests including trail making A (F (1,16) = 7.399, P = 0.0151, Figure 3a), trail making B (F (1,16) = 8.409, P = 0.0104, Figure 3b), digit span forward (F (1,16) = 8.696, P = 0.0094, Figure 3c), verbal paired associates immediate memory (F(1,16) = 6.485, P = 0.0215, Figure 3e) and digit symbol (F(1,16) = 24.209, P = 0.0002, Figure 3g), and no significant effects of repeated testing and drugs on test scoring without a significant interaction in other tests such as digit span backward (Figure 3d) and verbal paired associates delayed recall (Figure 3f).

Bottom Line: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude.Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate.The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan. fukami@faculty.chiba-u.jp.

ABSTRACT

Background: Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects.

Methods: Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically (14 days). The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test, trail making test, digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning.

Results: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore, subchronic administration of etizolam, but not ethyl loflazepate, still caused a weak prolongation in P300 latency. In contrast, neuropsychological tests showed no difference.

Conclusions: The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

No MeSH data available.


Related in: MedlinePlus