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Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.

Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, Hashimoto K, Iyo M - Ann Gen Psychiatry (2010)

Bottom Line: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude.Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate.The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan. fukami@faculty.chiba-u.jp.

ABSTRACT

Background: Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects.

Methods: Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically (14 days). The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test, trail making test, digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning.

Results: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore, subchronic administration of etizolam, but not ethyl loflazepate, still caused a weak prolongation in P300 latency. In contrast, neuropsychological tests showed no difference.

Conclusions: The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

No MeSH data available.


Related in: MedlinePlus

Effects of subchronic treatments with etizolam and ethyl loflazepate on P300. *P < 0.05 compared to pretreatment (repeated analysis of variance (ANOVA)).
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Figure 2: Effects of subchronic treatments with etizolam and ethyl loflazepate on P300. *P < 0.05 compared to pretreatment (repeated analysis of variance (ANOVA)).

Mentions: For subchronic drug treatment on the P300, two-way repeated ANOVA indicated significant effects of treatment region specifically (Fz, F (1,15) = 7.734, P = 0.0140; but see Cz, F (1,15) = 2.391, P = 0.1491; Pz, F (1,15) = 0.954, P = 0.3443), but not effects of group, on latency, without a significant interaction (Figure 2a-c). The subsequent Student t test on the changes of P300 latency revealed no significant difference between two drugs (Figure 2g-i). With regard to amplitude, two-way repeated ANOVA indicated no significant effects of treatment without a significant interaction (Figure 2d-f, j-l).


Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects.

Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, Hashimoto K, Iyo M - Ann Gen Psychiatry (2010)

Effects of subchronic treatments with etizolam and ethyl loflazepate on P300. *P < 0.05 compared to pretreatment (repeated analysis of variance (ANOVA)).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991318&req=5

Figure 2: Effects of subchronic treatments with etizolam and ethyl loflazepate on P300. *P < 0.05 compared to pretreatment (repeated analysis of variance (ANOVA)).
Mentions: For subchronic drug treatment on the P300, two-way repeated ANOVA indicated significant effects of treatment region specifically (Fz, F (1,15) = 7.734, P = 0.0140; but see Cz, F (1,15) = 2.391, P = 0.1491; Pz, F (1,15) = 0.954, P = 0.3443), but not effects of group, on latency, without a significant interaction (Figure 2a-c). The subsequent Student t test on the changes of P300 latency revealed no significant difference between two drugs (Figure 2g-i). With regard to amplitude, two-way repeated ANOVA indicated no significant effects of treatment without a significant interaction (Figure 2d-f, j-l).

Bottom Line: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude.Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate.The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan. fukami@faculty.chiba-u.jp.

ABSTRACT

Background: Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects.

Methods: Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically (14 days). The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test, trail making test, digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning.

Results: Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore, subchronic administration of etizolam, but not ethyl loflazepate, still caused a weak prolongation in P300 latency. In contrast, neuropsychological tests showed no difference.

Conclusions: The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.

No MeSH data available.


Related in: MedlinePlus