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Diffusion tensor imaging (DTI) and colored fractional anisotropy (FA) mapping of the subthalamic nucleus (STN) and the globus pallidus interna (GPi).

Sedrak M, Gorgulho A, Bari A, Behnke E, Frew A, Gevorkyan I, Pouratian N, DeSalles A - Acta Neurochir (Wien) (2010)

Bottom Line: Colored FA maps resulted in a key signature in and around the STN and GPi.Colored FA maps allow a potential method to identify the STN and GPi accurately.DTI has proven to be a powerful tool that can be used to augment identification of the STN nucleus and GPi used for stereotactic surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University of California Los Angeles, 90095, USA. msedrak@gmail.com

ABSTRACT

Introduction: The subthalamic nucleus (STN) and the globus pallidus internus (GPi) are the most common surgical targets for the treatment of Parkinson's disease. We studied directionally colored fractional anisotropy (FA) and diffusion tensor imaging (DTI) sequences to better target these anatomical regions.

Methods: Four patients undergoing stereotactic surgery for movement disorders were studied. Stereotactic targets and fiber tractography were determined on MRIs using the Schaltenbrand-Wahren atlas for definition in the iPlan software. In addition, post-operative imaging was fused to preoperative FA sequences for end-result identification. Axial, sagittal, and coronal images of the FA sequence were studied. DTI parameters used ranged from 2 to 4 mm for voxel size in the x/y/z planes, fiber length was kept constant at 15 mm and FA threshold of 0.25.

Results: Colored FA maps resulted in a key signature in and around the STN and GPi. Regions identified include, but were not limited to: the internal capsule, nigral projections, the thalamic fasciculus, Forel's fields H1 and H2, zona incerta, suthalamic fasciculus, tegmental tracts, and cerebello-rubro-thalamic tract.

Conclusions: Colored FA maps allow a potential method to identify the STN and GPi accurately. DTI has proven to be a powerful tool that can be used to augment identification of the STN nucleus and GPi used for stereotactic surgery.

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Related in: MedlinePlus

DTI Imaging of the Pallidum and Subthalamic Region. Purple is pallidum, gold is STN. Fibers can be seen traversing portions of the subthalamic nucleus and the globus pallidus. Interconnectivity is seen (FA 0.25 and Min fiber length 15 mm)
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Fig4: DTI Imaging of the Pallidum and Subthalamic Region. Purple is pallidum, gold is STN. Fibers can be seen traversing portions of the subthalamic nucleus and the globus pallidus. Interconnectivity is seen (FA 0.25 and Min fiber length 15 mm)

Mentions: Region of interest (ROI) was placed in the STN/GPI nucleus as identified by the Schaltenbrand–Wahren atlas and efficacious electrode placement. Tractography of these ROIs demonstrated fibers entering or exiting the both nuclei (Fig. 4). These fibers included the ansa lenticularis, subthalamic tracts, and Forel’s field (FA 0.25 and minimum fiber length of 15 mm).Fig. 4


Diffusion tensor imaging (DTI) and colored fractional anisotropy (FA) mapping of the subthalamic nucleus (STN) and the globus pallidus interna (GPi).

Sedrak M, Gorgulho A, Bari A, Behnke E, Frew A, Gevorkyan I, Pouratian N, DeSalles A - Acta Neurochir (Wien) (2010)

DTI Imaging of the Pallidum and Subthalamic Region. Purple is pallidum, gold is STN. Fibers can be seen traversing portions of the subthalamic nucleus and the globus pallidus. Interconnectivity is seen (FA 0.25 and Min fiber length 15 mm)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2991232&req=5

Fig4: DTI Imaging of the Pallidum and Subthalamic Region. Purple is pallidum, gold is STN. Fibers can be seen traversing portions of the subthalamic nucleus and the globus pallidus. Interconnectivity is seen (FA 0.25 and Min fiber length 15 mm)
Mentions: Region of interest (ROI) was placed in the STN/GPI nucleus as identified by the Schaltenbrand–Wahren atlas and efficacious electrode placement. Tractography of these ROIs demonstrated fibers entering or exiting the both nuclei (Fig. 4). These fibers included the ansa lenticularis, subthalamic tracts, and Forel’s field (FA 0.25 and minimum fiber length of 15 mm).Fig. 4

Bottom Line: Colored FA maps resulted in a key signature in and around the STN and GPi.Colored FA maps allow a potential method to identify the STN and GPi accurately.DTI has proven to be a powerful tool that can be used to augment identification of the STN nucleus and GPi used for stereotactic surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University of California Los Angeles, 90095, USA. msedrak@gmail.com

ABSTRACT

Introduction: The subthalamic nucleus (STN) and the globus pallidus internus (GPi) are the most common surgical targets for the treatment of Parkinson's disease. We studied directionally colored fractional anisotropy (FA) and diffusion tensor imaging (DTI) sequences to better target these anatomical regions.

Methods: Four patients undergoing stereotactic surgery for movement disorders were studied. Stereotactic targets and fiber tractography were determined on MRIs using the Schaltenbrand-Wahren atlas for definition in the iPlan software. In addition, post-operative imaging was fused to preoperative FA sequences for end-result identification. Axial, sagittal, and coronal images of the FA sequence were studied. DTI parameters used ranged from 2 to 4 mm for voxel size in the x/y/z planes, fiber length was kept constant at 15 mm and FA threshold of 0.25.

Results: Colored FA maps resulted in a key signature in and around the STN and GPi. Regions identified include, but were not limited to: the internal capsule, nigral projections, the thalamic fasciculus, Forel's fields H1 and H2, zona incerta, suthalamic fasciculus, tegmental tracts, and cerebello-rubro-thalamic tract.

Conclusions: Colored FA maps allow a potential method to identify the STN and GPi accurately. DTI has proven to be a powerful tool that can be used to augment identification of the STN nucleus and GPi used for stereotactic surgery.

Show MeSH
Related in: MedlinePlus