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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents.

Jeong SY, Kim HJ, Kwak BK, Lee HY, Seong H, Shin BC, Yuk SH, Hwang SJ, Cho SH - Nanoscale Res Lett (2010)

Bottom Line: All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR).Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent.Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

No MeSH data available.


Electron microscopic observation of Kupffer cells at 30 min after injection of a OmniscanTM and b PHEA-mPEG-C16-ED-DOTA-Gd
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Figure 6: Electron microscopic observation of Kupffer cells at 30 min after injection of a OmniscanTM and b PHEA-mPEG-C16-ED-DOTA-Gd

Mentions: Electron microscopic observation of the hepatic Kupffer cells showed that phagocytosis of PHEA-mPEG-C16-ED-DOTA-Gd by lysosomes was much greater compared to that of Omniscan® (Fig. 6).


Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents.

Jeong SY, Kim HJ, Kwak BK, Lee HY, Seong H, Shin BC, Yuk SH, Hwang SJ, Cho SH - Nanoscale Res Lett (2010)

Electron microscopic observation of Kupffer cells at 30 min after injection of a OmniscanTM and b PHEA-mPEG-C16-ED-DOTA-Gd
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2991228&req=5

Figure 6: Electron microscopic observation of Kupffer cells at 30 min after injection of a OmniscanTM and b PHEA-mPEG-C16-ED-DOTA-Gd
Mentions: Electron microscopic observation of the hepatic Kupffer cells showed that phagocytosis of PHEA-mPEG-C16-ED-DOTA-Gd by lysosomes was much greater compared to that of Omniscan® (Fig. 6).

Bottom Line: All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR).Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent.Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

No MeSH data available.