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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents.

Jeong SY, Kim HJ, Kwak BK, Lee HY, Seong H, Shin BC, Yuk SH, Hwang SJ, Cho SH - Nanoscale Res Lett (2010)

Bottom Line: All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR).Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent.Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

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ABSTRACT
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

No MeSH data available.


T1-weighted MR phantom image of PHEA-mPEG-C16-ED-DOTA-Gd and Omniscan®
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Figure 4: T1-weighted MR phantom image of PHEA-mPEG-C16-ED-DOTA-Gd and Omniscan®

Mentions: T1-weighted MRI images of phantom are showed in Fig. 4. The signal intensity increased more obviously in phantom prepared with PHEA-mPEG-C16-ED-DOTA-Gd, in comparison with phantom prepared with Omniscan®. Image contrast showed similar patterns. These results showed that prepared sample had better contrast imaging in smaller amount more than Omniscan®. The reason seems that DOTA-Gd on PHEA backbone is aggregated closely.


Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents.

Jeong SY, Kim HJ, Kwak BK, Lee HY, Seong H, Shin BC, Yuk SH, Hwang SJ, Cho SH - Nanoscale Res Lett (2010)

T1-weighted MR phantom image of PHEA-mPEG-C16-ED-DOTA-Gd and Omniscan®
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2991228&req=5

Figure 4: T1-weighted MR phantom image of PHEA-mPEG-C16-ED-DOTA-Gd and Omniscan®
Mentions: T1-weighted MRI images of phantom are showed in Fig. 4. The signal intensity increased more obviously in phantom prepared with PHEA-mPEG-C16-ED-DOTA-Gd, in comparison with phantom prepared with Omniscan®. Image contrast showed similar patterns. These results showed that prepared sample had better contrast imaging in smaller amount more than Omniscan®. The reason seems that DOTA-Gd on PHEA backbone is aggregated closely.

Bottom Line: All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR).Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent.Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.

No MeSH data available.