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Pulvinar projections to the striatum and amygdala in the tree shrew.

Day-Brown JD, Wei H, Chomsung RD, Petry HM, Bickford ME - Front Neuroanat (2010)

Bottom Line: Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus.Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix.Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomical Sciences and Neurobiology, University of Louisville Medical Center Louisville, KY, USA.

ABSTRACT
Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as "blindsight." Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus. To define potential pathways that underlie behavioral responses to unperceived visual stimuli, we examined the projections from the pulvinar nucleus to the striatum and amygdala in the tree shrew (Tupaia belangeri), a species considered to be a prototypical primate. The tree shrew brain has a large pulvinar nucleus that contains two SC-recipient subdivisions; the dorsal (Pd) and central (Pc) pulvinar both receive topographic ("specific") projections from SC, and Pd receives an additional non-topographic ("diffuse") projection from SC (Chomsung et al., 2008). Anterograde and retrograde tract tracing revealed that both Pd and Pc project to the caudate and putamen, and Pd, but not Pc, additionally projects to the lateral amygdala. Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix. Confocal microscopy revealed that tracer-labeled pulvino-striatal terminals preferentially innervate the matrix. Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images.

No MeSH data available.


Related in: MedlinePlus

The potential influence of dorsal (Pd) and central (Pc) pulvinar projections on basal ganglia circuits and behavior initiated by the superior colliculus (SC). Left side of figure: the Pd and Pc receive topographically arranged inputs from the SC (“specific”) and project to spiny output cells in the matrix (dark green) of the caudate (Cd) and putamen (PUT). GABAergic spiny cells of the Cd and PUT project to the substantia nigra pars reticulate (SNr) and GABAergic nigrotectal cells densely innervate the cells of origin of the crossed predorsal bundle (PDB). Tecto-pulvino-striatal projections could initiate pursuit movements mediated by the PDB. Right side of figure: the Pd receives additional non-topographic, convergent projections from the SC (“diffuse”) and projects to spiny output cells of the lateral amygdala (La). The La projects to the PUT and central amygdala (Ce). The Ce projects to the dopaminergic substantia nigra pars compacata (SNc). Tecto-pulvino-amygdala projections could serve to amplify escape movements mediated by the ipsilateral cuneiform (CNF) pathway. See text for details.
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Figure 6: The potential influence of dorsal (Pd) and central (Pc) pulvinar projections on basal ganglia circuits and behavior initiated by the superior colliculus (SC). Left side of figure: the Pd and Pc receive topographically arranged inputs from the SC (“specific”) and project to spiny output cells in the matrix (dark green) of the caudate (Cd) and putamen (PUT). GABAergic spiny cells of the Cd and PUT project to the substantia nigra pars reticulate (SNr) and GABAergic nigrotectal cells densely innervate the cells of origin of the crossed predorsal bundle (PDB). Tecto-pulvino-striatal projections could initiate pursuit movements mediated by the PDB. Right side of figure: the Pd receives additional non-topographic, convergent projections from the SC (“diffuse”) and projects to spiny output cells of the lateral amygdala (La). The La projects to the PUT and central amygdala (Ce). The Ce projects to the dopaminergic substantia nigra pars compacata (SNc). Tecto-pulvino-amygdala projections could serve to amplify escape movements mediated by the ipsilateral cuneiform (CNF) pathway. See text for details.

Mentions: Figure 6 schematically illustrates the potential influence of pulvinar projections on basal ganglia circuits and behavior initiated by the SC. The current results and those of our previous study of tectopulvinar projections (Chomsung et al., 2008) indicate that visual information from the SC is relayed via the pulvinar nucleus to the spiny output cells of the striatum matrix and the lateral amygdala. As discussed below, we suggest that the specific projections from the SC to the Pd and Pc relay topographic visual information to the striatum to aid in guiding precise movements related to pursuit of non-threatening objects, while the diffuse projections from the SC to the Pd relay non-topographic visual information to the amygdala to alert the animal to potential danger and initiate escape behavior.


Pulvinar projections to the striatum and amygdala in the tree shrew.

Day-Brown JD, Wei H, Chomsung RD, Petry HM, Bickford ME - Front Neuroanat (2010)

The potential influence of dorsal (Pd) and central (Pc) pulvinar projections on basal ganglia circuits and behavior initiated by the superior colliculus (SC). Left side of figure: the Pd and Pc receive topographically arranged inputs from the SC (“specific”) and project to spiny output cells in the matrix (dark green) of the caudate (Cd) and putamen (PUT). GABAergic spiny cells of the Cd and PUT project to the substantia nigra pars reticulate (SNr) and GABAergic nigrotectal cells densely innervate the cells of origin of the crossed predorsal bundle (PDB). Tecto-pulvino-striatal projections could initiate pursuit movements mediated by the PDB. Right side of figure: the Pd receives additional non-topographic, convergent projections from the SC (“diffuse”) and projects to spiny output cells of the lateral amygdala (La). The La projects to the PUT and central amygdala (Ce). The Ce projects to the dopaminergic substantia nigra pars compacata (SNc). Tecto-pulvino-amygdala projections could serve to amplify escape movements mediated by the ipsilateral cuneiform (CNF) pathway. See text for details.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2991220&req=5

Figure 6: The potential influence of dorsal (Pd) and central (Pc) pulvinar projections on basal ganglia circuits and behavior initiated by the superior colliculus (SC). Left side of figure: the Pd and Pc receive topographically arranged inputs from the SC (“specific”) and project to spiny output cells in the matrix (dark green) of the caudate (Cd) and putamen (PUT). GABAergic spiny cells of the Cd and PUT project to the substantia nigra pars reticulate (SNr) and GABAergic nigrotectal cells densely innervate the cells of origin of the crossed predorsal bundle (PDB). Tecto-pulvino-striatal projections could initiate pursuit movements mediated by the PDB. Right side of figure: the Pd receives additional non-topographic, convergent projections from the SC (“diffuse”) and projects to spiny output cells of the lateral amygdala (La). The La projects to the PUT and central amygdala (Ce). The Ce projects to the dopaminergic substantia nigra pars compacata (SNc). Tecto-pulvino-amygdala projections could serve to amplify escape movements mediated by the ipsilateral cuneiform (CNF) pathway. See text for details.
Mentions: Figure 6 schematically illustrates the potential influence of pulvinar projections on basal ganglia circuits and behavior initiated by the SC. The current results and those of our previous study of tectopulvinar projections (Chomsung et al., 2008) indicate that visual information from the SC is relayed via the pulvinar nucleus to the spiny output cells of the striatum matrix and the lateral amygdala. As discussed below, we suggest that the specific projections from the SC to the Pd and Pc relay topographic visual information to the striatum to aid in guiding precise movements related to pursuit of non-threatening objects, while the diffuse projections from the SC to the Pd relay non-topographic visual information to the amygdala to alert the animal to potential danger and initiate escape behavior.

Bottom Line: Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus.Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix.Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomical Sciences and Neurobiology, University of Louisville Medical Center Louisville, KY, USA.

ABSTRACT
Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as "blindsight." Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus. To define potential pathways that underlie behavioral responses to unperceived visual stimuli, we examined the projections from the pulvinar nucleus to the striatum and amygdala in the tree shrew (Tupaia belangeri), a species considered to be a prototypical primate. The tree shrew brain has a large pulvinar nucleus that contains two SC-recipient subdivisions; the dorsal (Pd) and central (Pc) pulvinar both receive topographic ("specific") projections from SC, and Pd receives an additional non-topographic ("diffuse") projection from SC (Chomsung et al., 2008). Anterograde and retrograde tract tracing revealed that both Pd and Pc project to the caudate and putamen, and Pd, but not Pc, additionally projects to the lateral amygdala. Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix. Confocal microscopy revealed that tracer-labeled pulvino-striatal terminals preferentially innervate the matrix. Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images.

No MeSH data available.


Related in: MedlinePlus