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Combined optical coherence tomography and intravascular ultrasound radio frequency data analysis for plaque characterization. Classification accuracy of human coronary plaques in vitro.

Goderie TP, van Soest G, Garcia-Garcia HM, Gonzalo N, Koljenović S, van Leenders GJ, Mastik F, Regar E, Oosterhuis JW, Serruys PW, van der Steen AF - Int J Cardiovasc Imaging (2010)

Bottom Line: Imaging with both modalities and coregistered histology was successful in 36 sections.Typical image artifacts were found to affect the interpretation of OCT data, misclassifying intimal thickening as fibroatheroma or thin-cap fibroatheroma.Adding VH-IVUS to OCT reduced the error rate in this study.

View Article: PubMed Central - PubMed

Affiliation: Thorax Center Biomedical Engineering, Erasmus MC Rotterdam, Rotterdam, The Netherlands.

ABSTRACT
This study was performed to characterize coronary plaque types by optical coherence tomography (OCT) and intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, and to investigate the possibility of error reduction by combining these techniques. Intracoronary imaging methods have greatly enhanced the diagnostic capabilities for the detection of high-risk atherosclerotic plaques. IVUS RF data analysis and OCT are two techniques focusing on plaque morphology and composition. Regions of interest were selected and imaged with OCT and IVUS in 50 sections, from 14 human coronary arteries, sectioned post-mortem from 14 hearts of patients dying of non-cardiovascular causes. Plaques were classified based on IVUS RF data analysis (VH-IVUS(TM)), OCT and the combination of those. Histology was the benchmark. Imaging with both modalities and coregistered histology was successful in 36 sections. OCT correctly classified 24; VH-IVUS 25, and VH-IVUS/OCT combined, 27 out of 36 cross-sections. Systematic misclassifications in OCT were intimal thickening classified as fibroatheroma in 8 cross-sections. Misclassifications in VH-IVUS were mainly fibroatheroma as intimal thickening in 5 cross-sections. Typical image artifacts were found to affect the interpretation of OCT data, misclassifying intimal thickening as fibroatheroma or thin-cap fibroatheroma. Adding VH-IVUS to OCT reduced the error rate in this study.

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a Histology of a calcified fibroatheroma. b Corresponding VH-IVUS classified as calcified fibroatheroma. c Corresponding OCT classified as calcified fibroatheroma. The needle used to mark the site can be seen in the bright feature at 6 o’clock in OCT, as well as in the appearance of dense calcium in that location in VH-IVUS
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Fig2: a Histology of a calcified fibroatheroma. b Corresponding VH-IVUS classified as calcified fibroatheroma. c Corresponding OCT classified as calcified fibroatheroma. The needle used to mark the site can be seen in the bright feature at 6 o’clock in OCT, as well as in the appearance of dense calcium in that location in VH-IVUS

Mentions: The results in Table 2 demonstrate that the classifications by both OCT and VH-IVUS agree with histology in most cases. Figure 2 illustrates a representative example, where both OCT and VH detect a fibroatheroma (with calcification), which is in accordance with the histological classification. We found that plaque classification by OCT and VH-IVUS combined was successful in more cross-sections than either technology alone, although the differences are small.Fig. 2


Combined optical coherence tomography and intravascular ultrasound radio frequency data analysis for plaque characterization. Classification accuracy of human coronary plaques in vitro.

Goderie TP, van Soest G, Garcia-Garcia HM, Gonzalo N, Koljenović S, van Leenders GJ, Mastik F, Regar E, Oosterhuis JW, Serruys PW, van der Steen AF - Int J Cardiovasc Imaging (2010)

a Histology of a calcified fibroatheroma. b Corresponding VH-IVUS classified as calcified fibroatheroma. c Corresponding OCT classified as calcified fibroatheroma. The needle used to mark the site can be seen in the bright feature at 6 o’clock in OCT, as well as in the appearance of dense calcium in that location in VH-IVUS
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2991172&req=5

Fig2: a Histology of a calcified fibroatheroma. b Corresponding VH-IVUS classified as calcified fibroatheroma. c Corresponding OCT classified as calcified fibroatheroma. The needle used to mark the site can be seen in the bright feature at 6 o’clock in OCT, as well as in the appearance of dense calcium in that location in VH-IVUS
Mentions: The results in Table 2 demonstrate that the classifications by both OCT and VH-IVUS agree with histology in most cases. Figure 2 illustrates a representative example, where both OCT and VH detect a fibroatheroma (with calcification), which is in accordance with the histological classification. We found that plaque classification by OCT and VH-IVUS combined was successful in more cross-sections than either technology alone, although the differences are small.Fig. 2

Bottom Line: Imaging with both modalities and coregistered histology was successful in 36 sections.Typical image artifacts were found to affect the interpretation of OCT data, misclassifying intimal thickening as fibroatheroma or thin-cap fibroatheroma.Adding VH-IVUS to OCT reduced the error rate in this study.

View Article: PubMed Central - PubMed

Affiliation: Thorax Center Biomedical Engineering, Erasmus MC Rotterdam, Rotterdam, The Netherlands.

ABSTRACT
This study was performed to characterize coronary plaque types by optical coherence tomography (OCT) and intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, and to investigate the possibility of error reduction by combining these techniques. Intracoronary imaging methods have greatly enhanced the diagnostic capabilities for the detection of high-risk atherosclerotic plaques. IVUS RF data analysis and OCT are two techniques focusing on plaque morphology and composition. Regions of interest were selected and imaged with OCT and IVUS in 50 sections, from 14 human coronary arteries, sectioned post-mortem from 14 hearts of patients dying of non-cardiovascular causes. Plaques were classified based on IVUS RF data analysis (VH-IVUS(TM)), OCT and the combination of those. Histology was the benchmark. Imaging with both modalities and coregistered histology was successful in 36 sections. OCT correctly classified 24; VH-IVUS 25, and VH-IVUS/OCT combined, 27 out of 36 cross-sections. Systematic misclassifications in OCT were intimal thickening classified as fibroatheroma in 8 cross-sections. Misclassifications in VH-IVUS were mainly fibroatheroma as intimal thickening in 5 cross-sections. Typical image artifacts were found to affect the interpretation of OCT data, misclassifying intimal thickening as fibroatheroma or thin-cap fibroatheroma. Adding VH-IVUS to OCT reduced the error rate in this study.

Show MeSH
Related in: MedlinePlus