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Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.

Massoner P, Ladurner-Rennau M, Eder IE, Klocker H - Br. J. Cancer (2010)

Bottom Line: Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis.We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis.Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

View Article: PubMed Central - PubMed

Affiliation: Section of Experimental Urology, Department of Urology, Innsbruck Medical University, Anichstr. 35, Innsbruck 6020, Austria. Petra.Massoner@i-med.ac.at

ABSTRACT
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

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The IGF/INS axis is a complex multilayer interacting molecular network with multiple effects.
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fig1: The IGF/INS axis is a complex multilayer interacting molecular network with multiple effects.

Mentions: We do not entirely know how the IGF/INS axis mediates these multiple functions, but experimental data have shown that dynamic and multilayer IGF/INS interactions, and cross talks of the IGF/INS axis to other receptor tyrosine kinase pathways, such as the epidermal growth factor receptor (EGFR) pathway, generate variable IGF/INS signals in different cell types and tissues. The different layers of diversity of signalling that give rise to the multiple functions of the IGF/INS axis are schematically shown in Figure 1 and explained in the following chapters. The variety of cellular responses to the IGF/INS signal depend, on one hand, on the availability of growth factors and the ratios of the receptors and signalling molecules, and, on the other hand, on the cell and tissue type and the tissue microenvironment.


Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.

Massoner P, Ladurner-Rennau M, Eder IE, Klocker H - Br. J. Cancer (2010)

The IGF/INS axis is a complex multilayer interacting molecular network with multiple effects.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2990579&req=5

fig1: The IGF/INS axis is a complex multilayer interacting molecular network with multiple effects.
Mentions: We do not entirely know how the IGF/INS axis mediates these multiple functions, but experimental data have shown that dynamic and multilayer IGF/INS interactions, and cross talks of the IGF/INS axis to other receptor tyrosine kinase pathways, such as the epidermal growth factor receptor (EGFR) pathway, generate variable IGF/INS signals in different cell types and tissues. The different layers of diversity of signalling that give rise to the multiple functions of the IGF/INS axis are schematically shown in Figure 1 and explained in the following chapters. The variety of cellular responses to the IGF/INS signal depend, on one hand, on the availability of growth factors and the ratios of the receptors and signalling molecules, and, on the other hand, on the cell and tissue type and the tissue microenvironment.

Bottom Line: Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis.We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis.Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

View Article: PubMed Central - PubMed

Affiliation: Section of Experimental Urology, Department of Urology, Innsbruck Medical University, Anichstr. 35, Innsbruck 6020, Austria. Petra.Massoner@i-med.ac.at

ABSTRACT
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.

Show MeSH
Related in: MedlinePlus