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Undifferentiated Endometrial Sarcoma of the Ovary: A Case Report with Review of Recent Literature and Discussion of Lacking Specificity of CD10 Immunoreactivity.

Brustmann H, Geiss IM, Hinterholzer S - Patholog Res Int (2009)

Bottom Line: Tumor cells showed diffuse strong immunoreactivity for vimentin and patchy strong staining for CD10; no reactivities were found for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31.CD10 is frequently expressed in different gynecopathological as well as other lesions, and, thus, nonspecific without relevance to the classification of this case.Morphological features, extensive sampling, and appropriate immunohistochemistry including markers for cytokeratins and myogenic differentiation are mandatory to arrive at the correct diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Landesklinikum Thermenregion Mödling, Sr. M. Restitutagasse 12, Mödling A-2340, Austria.

ABSTRACT
Undifferentiated endometrial sarcomas (UESs) of the ovary are very rare tumors. This paper presents a case of a 56-year-old patient with a history of hysterectomy and bilateral salpingectomy seven years ago for uterine leiomyomata. Intraoperatively, a tumor originating from the left ovary, adherent to the sigmoid colon, with infiltration of the small intestine and the vaginal apex was found. Histologically, the tumor was composed of pleomorphic round and oval to spindled cells with polymorphous vesicular nuclei with coarse chromatin and large nucleoli. Mitotic activity was brisk. There were large necrotic areas. Adjacent to the tumor tissue endometrium-like glands surrounded by fibrous stroma with macrophages corresponding to ovarian endometriosis were noted. Tumor cells showed diffuse strong immunoreactivity for vimentin and patchy strong staining for CD10; no reactivities were found for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31. The patient died of her neoplastic disease four months postoperatively. CD10 is frequently expressed in different gynecopathological as well as other lesions, and, thus, nonspecific without relevance to the classification of this case. Morphological features, extensive sampling, and appropriate immunohistochemistry including markers for cytokeratins and myogenic differentiation are mandatory to arrive at the correct diagnosis.

No MeSH data available.


Related in: MedlinePlus

Tumor cells of high grade ovarian UES show focal strong immunostaining for CD10 (×400).
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fig4: Tumor cells of high grade ovarian UES show focal strong immunostaining for CD10 (×400).

Mentions: Immunohistochemically, tumor cells showed diffuse strong reactivity for vimentin and patchy strong staining for CD10 in about 50% of cells (Figure 4); there was no staining of tumor cells for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31. Estrogen and progesterone receptor reactivities were noted focally in a small percentage of neoplastic cells only. In some tumor areas, up to 60% of tumor cells reacted for MIB-1. Endometriotic glands showed abundant nuclear immunostaining for hormone receptors.


Undifferentiated Endometrial Sarcoma of the Ovary: A Case Report with Review of Recent Literature and Discussion of Lacking Specificity of CD10 Immunoreactivity.

Brustmann H, Geiss IM, Hinterholzer S - Patholog Res Int (2009)

Tumor cells of high grade ovarian UES show focal strong immunostaining for CD10 (×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2990339&req=5

fig4: Tumor cells of high grade ovarian UES show focal strong immunostaining for CD10 (×400).
Mentions: Immunohistochemically, tumor cells showed diffuse strong reactivity for vimentin and patchy strong staining for CD10 in about 50% of cells (Figure 4); there was no staining of tumor cells for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31. Estrogen and progesterone receptor reactivities were noted focally in a small percentage of neoplastic cells only. In some tumor areas, up to 60% of tumor cells reacted for MIB-1. Endometriotic glands showed abundant nuclear immunostaining for hormone receptors.

Bottom Line: Tumor cells showed diffuse strong immunoreactivity for vimentin and patchy strong staining for CD10; no reactivities were found for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31.CD10 is frequently expressed in different gynecopathological as well as other lesions, and, thus, nonspecific without relevance to the classification of this case.Morphological features, extensive sampling, and appropriate immunohistochemistry including markers for cytokeratins and myogenic differentiation are mandatory to arrive at the correct diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Landesklinikum Thermenregion Mödling, Sr. M. Restitutagasse 12, Mödling A-2340, Austria.

ABSTRACT
Undifferentiated endometrial sarcomas (UESs) of the ovary are very rare tumors. This paper presents a case of a 56-year-old patient with a history of hysterectomy and bilateral salpingectomy seven years ago for uterine leiomyomata. Intraoperatively, a tumor originating from the left ovary, adherent to the sigmoid colon, with infiltration of the small intestine and the vaginal apex was found. Histologically, the tumor was composed of pleomorphic round and oval to spindled cells with polymorphous vesicular nuclei with coarse chromatin and large nucleoli. Mitotic activity was brisk. There were large necrotic areas. Adjacent to the tumor tissue endometrium-like glands surrounded by fibrous stroma with macrophages corresponding to ovarian endometriosis were noted. Tumor cells showed diffuse strong immunoreactivity for vimentin and patchy strong staining for CD10; no reactivities were found for AE1/AE3, desmin, S-100, LCA, CD20, c-kit, and CD31. The patient died of her neoplastic disease four months postoperatively. CD10 is frequently expressed in different gynecopathological as well as other lesions, and, thus, nonspecific without relevance to the classification of this case. Morphological features, extensive sampling, and appropriate immunohistochemistry including markers for cytokeratins and myogenic differentiation are mandatory to arrive at the correct diagnosis.

No MeSH data available.


Related in: MedlinePlus