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Mixed hepatoblastoma in a young male adult: a case report and literature review.

Fiaschetti V, Fiori R, Gaspari E, Crusco S, Simonetti G - Case Rep Med (2010)

Bottom Line: Most of these tumours arise in the embryo; hence it seems to be unusual that hepatoblastoma occurs in adults and is an exceptional cause of primary malignant liver tumour in adult patients.The diagnosis is often overlooked, and patients might be diagnosed at late stages of the disease at risk of increased mortality.The MRI detects tumor features as size, margins, and ratio with neighboring organs in order to get the best surgical approach.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Policlinico Universitario "Tor Vergata", Viale Oxford 81, 00133 Roma, Italy.

ABSTRACT
Hepatoblastoma (HB) is a rare malignant tumour of the liver and usually occurs in the first three years of life. Most of these tumours arise in the embryo; hence it seems to be unusual that hepatoblastoma occurs in adults and is an exceptional cause of primary malignant liver tumour in adult patients. The diagnosis is often overlooked, and patients might be diagnosed at late stages of the disease at risk of increased mortality. In this paper we report a case of a 30-year-old man with mixed hepatoblastoma and abdominal pain, hepatomegaly and fever. The patient under went noninvasive diagnostic methods: duplex scanning, Computed Tomography (CT), and Magnetic Resonance imaging (MRI). In our experience, despite the important role of histological sample provided by biopsy in defining the diagnosis, very important was the role of MRI, more than ultrasonography and enhanced CT. The MRI detects tumor features as size, margins, and ratio with neighboring organs in order to get the best surgical approach.

No MeSH data available.


Related in: MedlinePlus

Magnetic Resonance Imaging (MRI): axial T2-weighted images (a); axial T2-SPAIR weighted image (b); axial and coronal THRIVE (c–e); coronal balanced (f); T2-weighted images demonstrated a 23 × 14 × 13 cm heterogeneous mass in the right lobe (a-b). THRIVE images showed heterogeneous contrast enhanced with enhancement of fibrosis bands in tardive-phase (c–e). This heterogeneous mass occupied almost the whole right lobe of the liver presenting a well-defined capsule (f). 
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fig3: Magnetic Resonance Imaging (MRI): axial T2-weighted images (a); axial T2-SPAIR weighted image (b); axial and coronal THRIVE (c–e); coronal balanced (f); T2-weighted images demonstrated a 23 × 14 × 13 cm heterogeneous mass in the right lobe (a-b). THRIVE images showed heterogeneous contrast enhanced with enhancement of fibrosis bands in tardive-phase (c–e). This heterogeneous mass occupied almost the whole right lobe of the liver presenting a well-defined capsule (f). 

Mentions: Magnetic Resonance imaging (MRI) with contrast media demonstrated a 23 × 14 × 13 cm mass in the right lobe. This mass presented a well-defined capsule. T1-weighted images showed heterogeneous global intensity with areas with intensity signal similar to haemoglobin metabolites, areas with signal intensity similar to calcifications and area with signal intensity similar to fat. On T2-weighted images the lesion was hyperintense but heterogeneous because of hypointense areas corresponding to calcifications and bands corresponding to area of lobulation and fibrosis. Furthermore right kidney was displaced posteriorly by the mass with its vascular pedicle (Figure 3).


Mixed hepatoblastoma in a young male adult: a case report and literature review.

Fiaschetti V, Fiori R, Gaspari E, Crusco S, Simonetti G - Case Rep Med (2010)

Magnetic Resonance Imaging (MRI): axial T2-weighted images (a); axial T2-SPAIR weighted image (b); axial and coronal THRIVE (c–e); coronal balanced (f); T2-weighted images demonstrated a 23 × 14 × 13 cm heterogeneous mass in the right lobe (a-b). THRIVE images showed heterogeneous contrast enhanced with enhancement of fibrosis bands in tardive-phase (c–e). This heterogeneous mass occupied almost the whole right lobe of the liver presenting a well-defined capsule (f). 
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2990241&req=5

fig3: Magnetic Resonance Imaging (MRI): axial T2-weighted images (a); axial T2-SPAIR weighted image (b); axial and coronal THRIVE (c–e); coronal balanced (f); T2-weighted images demonstrated a 23 × 14 × 13 cm heterogeneous mass in the right lobe (a-b). THRIVE images showed heterogeneous contrast enhanced with enhancement of fibrosis bands in tardive-phase (c–e). This heterogeneous mass occupied almost the whole right lobe of the liver presenting a well-defined capsule (f). 
Mentions: Magnetic Resonance imaging (MRI) with contrast media demonstrated a 23 × 14 × 13 cm mass in the right lobe. This mass presented a well-defined capsule. T1-weighted images showed heterogeneous global intensity with areas with intensity signal similar to haemoglobin metabolites, areas with signal intensity similar to calcifications and area with signal intensity similar to fat. On T2-weighted images the lesion was hyperintense but heterogeneous because of hypointense areas corresponding to calcifications and bands corresponding to area of lobulation and fibrosis. Furthermore right kidney was displaced posteriorly by the mass with its vascular pedicle (Figure 3).

Bottom Line: Most of these tumours arise in the embryo; hence it seems to be unusual that hepatoblastoma occurs in adults and is an exceptional cause of primary malignant liver tumour in adult patients.The diagnosis is often overlooked, and patients might be diagnosed at late stages of the disease at risk of increased mortality.The MRI detects tumor features as size, margins, and ratio with neighboring organs in order to get the best surgical approach.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Policlinico Universitario "Tor Vergata", Viale Oxford 81, 00133 Roma, Italy.

ABSTRACT
Hepatoblastoma (HB) is a rare malignant tumour of the liver and usually occurs in the first three years of life. Most of these tumours arise in the embryo; hence it seems to be unusual that hepatoblastoma occurs in adults and is an exceptional cause of primary malignant liver tumour in adult patients. The diagnosis is often overlooked, and patients might be diagnosed at late stages of the disease at risk of increased mortality. In this paper we report a case of a 30-year-old man with mixed hepatoblastoma and abdominal pain, hepatomegaly and fever. The patient under went noninvasive diagnostic methods: duplex scanning, Computed Tomography (CT), and Magnetic Resonance imaging (MRI). In our experience, despite the important role of histological sample provided by biopsy in defining the diagnosis, very important was the role of MRI, more than ultrasonography and enhanced CT. The MRI detects tumor features as size, margins, and ratio with neighboring organs in order to get the best surgical approach.

No MeSH data available.


Related in: MedlinePlus