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Cardiovascular risk factors for incident hypertension in the prehypertensive population.

Kim SJ, Lee J, Jee SH, Nam CM, Chun K, Park IS, Lee SY - Epidemiol Health (2010)

Bottom Line: A total of 16,229 subjects, aged 30 to 54, with new onset preHTN at baseline (1994-1996) in a biennial national medical exam were selected and followed up till 2004 at 2-yr intervals.All subjects underwent a biennial health examination including biochemical measurements and behavior.According to the results of the Cox proportional hazard model, improvements in smoking (hazard ratio [HR], 0.756), drinking (HR, 0.669), regular exercise (HR, 0.653), body mass index (HR, 0.715), and total cholesterol (HR, 0.788) played a protective role in progression to HTN in men, while in women, participating in regular exercise (HR, 0.534) was beneficial.

View Article: PubMed Central - PubMed

Affiliation: Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives: The aim of this study was to investigate the effect of changes in cardiovascular disease (CVD) risk factors on progression from prehypertension (PreHTN) to hypertension (HTN) using an 8-yr prospective Korean Cancer Prevention Study (KCPS) by the National Health Insurance Corporation (NHIC) in Korea.

Methods: A total of 16,229 subjects, aged 30 to 54, with new onset preHTN at baseline (1994-1996) in a biennial national medical exam were selected and followed up till 2004 at 2-yr intervals. All subjects underwent a biennial health examination including biochemical measurements and behavior. The log-rank test was performed to assess the relationship between changes in CVD risk factors and progression to HTN. The Cox proportional hazard model was used to identify factors influencing progression to HTN.

Results: With regards the progression rate in men, ex-smokers (42.9%), abstainers (37.5%), and regular exercisers (37.6%) showed a slower progression rate than continuous smokers (49.5%) and continuous drinkers (50.9%). In women, those who participated in regular exercise (22.6%) had a lower rate of progression than continuous non-exercisers (36.1%). According to the results of the Cox proportional hazard model, improvements in smoking (hazard ratio [HR], 0.756), drinking (HR, 0.669), regular exercise (HR, 0.653), body mass index (HR, 0.715), and total cholesterol (HR, 0.788) played a protective role in progression to HTN in men, while in women, participating in regular exercise (HR, 0.534) was beneficial.

Conclusion: Improvements in CVD-related behaviors diminished the progression rate of HTN. This study suggests that individuals with PreHTN should be targeted for specific health behavioral intervention to prevent the progression of HTN.

No MeSH data available.


Related in: MedlinePlus

Data cleaning process for the study population.BMI, body mass index; SBP, systolic blood pressure; HTN, hypertension; DM, diabetes mellitus; DBP, diastolic blood pressure; FSG, fasting serum glucose; TC, total cholesterol.
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Figure 1: Data cleaning process for the study population.BMI, body mass index; SBP, systolic blood pressure; HTN, hypertension; DM, diabetes mellitus; DBP, diastolic blood pressure; FSG, fasting serum glucose; TC, total cholesterol.

Mentions: NHIC provides a national health insurance program for government employees, private school teachers and their dependents. The NHIC data include the KCPS data from 1,329,525 Koreans between the ages of 30 and 95 yr who underwent biennial medical evaluations. A total of 784,870 (59.0%) were enrolled in 1992, 367,903 (27.7%) in 1993, 98,417 (7.4%) in 1994, and 78,335 (5.9%) in 1995. A more detailed description of the subjects can be found elsewhere [14, 15]. In the present study, after randomly selecting 30% of the subjects from the KCPS data, various exclusion processes were carried out (Figure 1). The baseline data were collected in 1994 and 1996. The data from participants were examined at baseline and at follow-up health examinations in 1998, 2000, 2002, and 2004. The study included examinees who underwent the biennial health examination at least once or more over the period of 8 yr. Participants were excluded if they had PreHTN or HTN in 1992. The final sample consisted of 16,299 subjects with PreHTN at baseline (1994-1996) who were followed every other year until 2004. The study protocol was approved by the Yonsei University College of Medicine ethical committee.


Cardiovascular risk factors for incident hypertension in the prehypertensive population.

Kim SJ, Lee J, Jee SH, Nam CM, Chun K, Park IS, Lee SY - Epidemiol Health (2010)

Data cleaning process for the study population.BMI, body mass index; SBP, systolic blood pressure; HTN, hypertension; DM, diabetes mellitus; DBP, diastolic blood pressure; FSG, fasting serum glucose; TC, total cholesterol.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2984864&req=5

Figure 1: Data cleaning process for the study population.BMI, body mass index; SBP, systolic blood pressure; HTN, hypertension; DM, diabetes mellitus; DBP, diastolic blood pressure; FSG, fasting serum glucose; TC, total cholesterol.
Mentions: NHIC provides a national health insurance program for government employees, private school teachers and their dependents. The NHIC data include the KCPS data from 1,329,525 Koreans between the ages of 30 and 95 yr who underwent biennial medical evaluations. A total of 784,870 (59.0%) were enrolled in 1992, 367,903 (27.7%) in 1993, 98,417 (7.4%) in 1994, and 78,335 (5.9%) in 1995. A more detailed description of the subjects can be found elsewhere [14, 15]. In the present study, after randomly selecting 30% of the subjects from the KCPS data, various exclusion processes were carried out (Figure 1). The baseline data were collected in 1994 and 1996. The data from participants were examined at baseline and at follow-up health examinations in 1998, 2000, 2002, and 2004. The study included examinees who underwent the biennial health examination at least once or more over the period of 8 yr. Participants were excluded if they had PreHTN or HTN in 1992. The final sample consisted of 16,299 subjects with PreHTN at baseline (1994-1996) who were followed every other year until 2004. The study protocol was approved by the Yonsei University College of Medicine ethical committee.

Bottom Line: A total of 16,229 subjects, aged 30 to 54, with new onset preHTN at baseline (1994-1996) in a biennial national medical exam were selected and followed up till 2004 at 2-yr intervals.All subjects underwent a biennial health examination including biochemical measurements and behavior.According to the results of the Cox proportional hazard model, improvements in smoking (hazard ratio [HR], 0.756), drinking (HR, 0.669), regular exercise (HR, 0.653), body mass index (HR, 0.715), and total cholesterol (HR, 0.788) played a protective role in progression to HTN in men, while in women, participating in regular exercise (HR, 0.534) was beneficial.

View Article: PubMed Central - PubMed

Affiliation: Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT

Objectives: The aim of this study was to investigate the effect of changes in cardiovascular disease (CVD) risk factors on progression from prehypertension (PreHTN) to hypertension (HTN) using an 8-yr prospective Korean Cancer Prevention Study (KCPS) by the National Health Insurance Corporation (NHIC) in Korea.

Methods: A total of 16,229 subjects, aged 30 to 54, with new onset preHTN at baseline (1994-1996) in a biennial national medical exam were selected and followed up till 2004 at 2-yr intervals. All subjects underwent a biennial health examination including biochemical measurements and behavior. The log-rank test was performed to assess the relationship between changes in CVD risk factors and progression to HTN. The Cox proportional hazard model was used to identify factors influencing progression to HTN.

Results: With regards the progression rate in men, ex-smokers (42.9%), abstainers (37.5%), and regular exercisers (37.6%) showed a slower progression rate than continuous smokers (49.5%) and continuous drinkers (50.9%). In women, those who participated in regular exercise (22.6%) had a lower rate of progression than continuous non-exercisers (36.1%). According to the results of the Cox proportional hazard model, improvements in smoking (hazard ratio [HR], 0.756), drinking (HR, 0.669), regular exercise (HR, 0.653), body mass index (HR, 0.715), and total cholesterol (HR, 0.788) played a protective role in progression to HTN in men, while in women, participating in regular exercise (HR, 0.534) was beneficial.

Conclusion: Improvements in CVD-related behaviors diminished the progression rate of HTN. This study suggests that individuals with PreHTN should be targeted for specific health behavioral intervention to prevent the progression of HTN.

No MeSH data available.


Related in: MedlinePlus