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The 20 year evolution of dobutamine stress cardiovascular magnetic resonance.

Charoenpanichkit C, Hundley WG - J Cardiovasc Magn Reson (2010)

Bottom Line: Over the past 20 years, investigators world-wide have developed and utilized dobutamine magnetic resonance stress testing procedures for the purpose of identifying ischemia, viability, and cardiac prognosis.This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

ABSTRACT
Over the past 20 years, investigators world-wide have developed and utilized dobutamine magnetic resonance stress testing procedures for the purpose of identifying ischemia, viability, and cardiac prognosis. This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure.

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Related in: MedlinePlus

Sequence of events after coronary artery occlusion. Ischemic cascade represents the sequence of pathophysiological events following disruption of coronary artery blood flow.
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Figure 1: Sequence of events after coronary artery occlusion. Ischemic cascade represents the sequence of pathophysiological events following disruption of coronary artery blood flow.

Mentions: Dobutamine is a synthetic, primarily β1-adrenergic, catecholamine with mild α1- and β2-receptor agonist activity [1,2]. At low doses (≤ 10 μg/kg/min), dobutamine augments myocardial contractility and promotes coronary vasodilation [3]; at higher doses (20-40 μg/kg/min), it causes systematic vasodilation and serves as a positive chronotrope. These later effects increase heart rate and raise myocardial oxygen consumption by increasing myocardial work [4]. Dobutamine can be used during pharmacologic stress testing to identify inducible ischemia due to flow limiting epicardial coronary artery stenosis (Figure 1). Visually, this results in a LV perfusion or wall motion abnormality (WMA).


The 20 year evolution of dobutamine stress cardiovascular magnetic resonance.

Charoenpanichkit C, Hundley WG - J Cardiovasc Magn Reson (2010)

Sequence of events after coronary artery occlusion. Ischemic cascade represents the sequence of pathophysiological events following disruption of coronary artery blood flow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2984575&req=5

Figure 1: Sequence of events after coronary artery occlusion. Ischemic cascade represents the sequence of pathophysiological events following disruption of coronary artery blood flow.
Mentions: Dobutamine is a synthetic, primarily β1-adrenergic, catecholamine with mild α1- and β2-receptor agonist activity [1,2]. At low doses (≤ 10 μg/kg/min), dobutamine augments myocardial contractility and promotes coronary vasodilation [3]; at higher doses (20-40 μg/kg/min), it causes systematic vasodilation and serves as a positive chronotrope. These later effects increase heart rate and raise myocardial oxygen consumption by increasing myocardial work [4]. Dobutamine can be used during pharmacologic stress testing to identify inducible ischemia due to flow limiting epicardial coronary artery stenosis (Figure 1). Visually, this results in a LV perfusion or wall motion abnormality (WMA).

Bottom Line: Over the past 20 years, investigators world-wide have developed and utilized dobutamine magnetic resonance stress testing procedures for the purpose of identifying ischemia, viability, and cardiac prognosis.This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

ABSTRACT
Over the past 20 years, investigators world-wide have developed and utilized dobutamine magnetic resonance stress testing procedures for the purpose of identifying ischemia, viability, and cardiac prognosis. This article traces these developments and reviews the data utilized to substantiate this relatively new noninvasive imaging procedure.

Show MeSH
Related in: MedlinePlus