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Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

Liu Z, Li P, Zhao D, Tang H, Guo J - Behav Brain Funct (2010)

Bottom Line: The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines.Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function.The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R China.

ABSTRACT

Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.

Methods: The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively.

Results: Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.

Conclusions: These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.

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Related in: MedlinePlus

Effect of CSE on the Development of Behavioral Abnormalities after middle cerebral artery occlusion . Values are shown as means ± SEM. *p < 0.05 vs. MCAO group, **p < 0.01 vs. MCAO group. (FSHAM = 17.642, dfSHAM = 11, pSHAM = 0.001, F CSE-4 = 2.252, df CSE-4 = 11, p CSE-4 = 0.162, F CSE-8 = 16.396, df CSE-8 = 11, p CSE-8 = 0.01, F CSE-10 = 22.738, dfSHAM = 11, pSHAM = 0.02)
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Figure 1: Effect of CSE on the Development of Behavioral Abnormalities after middle cerebral artery occlusion . Values are shown as means ± SEM. *p < 0.05 vs. MCAO group, **p < 0.01 vs. MCAO group. (FSHAM = 17.642, dfSHAM = 11, pSHAM = 0.001, F CSE-4 = 2.252, df CSE-4 = 11, p CSE-4 = 0.162, F CSE-8 = 16.396, df CSE-8 = 11, p CSE-8 = 0.01, F CSE-10 = 22.738, dfSHAM = 11, pSHAM = 0.02)

Mentions: Twenty-four hours after MCAO in rats, neurological deficit scores were significantly reduced in CSE-8 -treated rats and CSE-10 -treated rats. The neurobehavior for the SHAM group was 0.9 (0.6--1.1), the MCAO group was 3.7 (2.6--5.3), the CSE-4 group was 2.2 (1.8--4.1), the CSE-8 group was 1.2 (0.8--4.1) and the CSE-10 group was 1.5 (1.0--4.1). It is clear that the behavioral abnormality was significantly developed in the MCAO group as compared with the sham (Figure 1). In contrast, the CSE-8 group and CSE-10 significantly suppressed the development of behavioral abnormality as compared with the MCAO group (Figure 1).


Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

Liu Z, Li P, Zhao D, Tang H, Guo J - Behav Brain Funct (2010)

Effect of CSE on the Development of Behavioral Abnormalities after middle cerebral artery occlusion . Values are shown as means ± SEM. *p < 0.05 vs. MCAO group, **p < 0.01 vs. MCAO group. (FSHAM = 17.642, dfSHAM = 11, pSHAM = 0.001, F CSE-4 = 2.252, df CSE-4 = 11, p CSE-4 = 0.162, F CSE-8 = 16.396, df CSE-8 = 11, p CSE-8 = 0.01, F CSE-10 = 22.738, dfSHAM = 11, pSHAM = 0.02)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2984477&req=5

Figure 1: Effect of CSE on the Development of Behavioral Abnormalities after middle cerebral artery occlusion . Values are shown as means ± SEM. *p < 0.05 vs. MCAO group, **p < 0.01 vs. MCAO group. (FSHAM = 17.642, dfSHAM = 11, pSHAM = 0.001, F CSE-4 = 2.252, df CSE-4 = 11, p CSE-4 = 0.162, F CSE-8 = 16.396, df CSE-8 = 11, p CSE-8 = 0.01, F CSE-10 = 22.738, dfSHAM = 11, pSHAM = 0.02)
Mentions: Twenty-four hours after MCAO in rats, neurological deficit scores were significantly reduced in CSE-8 -treated rats and CSE-10 -treated rats. The neurobehavior for the SHAM group was 0.9 (0.6--1.1), the MCAO group was 3.7 (2.6--5.3), the CSE-4 group was 2.2 (1.8--4.1), the CSE-8 group was 1.2 (0.8--4.1) and the CSE-10 group was 1.5 (1.0--4.1). It is clear that the behavioral abnormality was significantly developed in the MCAO group as compared with the sham (Figure 1). In contrast, the CSE-8 group and CSE-10 significantly suppressed the development of behavioral abnormality as compared with the MCAO group (Figure 1).

Bottom Line: The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines.Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function.The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R China.

ABSTRACT

Background: Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper.

Methods: The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively.

Results: Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.

Conclusions: These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.

Show MeSH
Related in: MedlinePlus