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Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report.

Faria GR, Eloy C, Preto JR, Costa EL, Almeida T, Barbosa J, Paiva ME, Sousa-Rodrigues J, Pimenta A - J Med Case Rep (2010)

Bottom Line: Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations.Adenosquamous gastric cancer is a rare diagnosis in western populations.The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

View Article: PubMed Central - HTML - PubMed

Affiliation: General Surgery Department, Hospital de São João/Faculty of Medicine at University of Porto, Alameda Prof, Hernâni Monteiro - Porto 4200-319, Portugal. dr.gilfaria@netcabo.pt.

ABSTRACT

Introduction: Most gastric tumors are adenocarcinomas. Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations. It constitutes less than one percent of all gastric carcinomas and its clinical presentation is the same as adenocarcinoma. It occurs more frequently in the proximal stomach, usually presents with muscular layer invasion and tends to be found in advanced stages at diagnosis, with a worse prognosis than adenocarcinoma.

Case presentation: We report the case of an 84-year-old Caucasian woman with an adenosquamous carcinoma extending to her serosa with lymphatic and venous invasion (T3N1M1). Nodal and hepatic metastasis presented with both cellular types, with dominance of the squamous component.

Conclusions: Adenosquamous gastric cancer is a rare diagnosis in western populations. We present the case of a woman with a very aggressive adenosquamous carcinoma with a preponderance of squamous cell component in the metastasis. Several origins have been proposed for this kind of carcinoma; either evolution from adenocarcinoma de-differentiation or stem cell origin might be possible. The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

No MeSH data available.


Related in: MedlinePlus

Histology - nodal metastasis (Hematoxylin and eosin staining).
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Figure 5: Histology - nodal metastasis (Hematoxylin and eosin staining).

Mentions: This allows us to classify the tumor as a carcinoma of the gastric antrum (AE1 AE3 and CAM5.2 positivity) with a glandular component, but predominantly epidermoid (approximately 80 percent). No neuroendocrine differentiation was observed (Cromogranin A and Sinaptophysinwere negative) and gastrointestinal stromal tumor (GIST) and melanoma were excluded (c-Kit, HMB-45 and S100 protein were negative). The tumor extended to her serosa with lymphatic and venous invasion, and presented with nodal and hepatic metastasis. The nodal (Figure 5) and hepatic (Figure 6) metastasis presented both cellular lines (squamous and glandular) but the majority was occupied by the squamous component.


Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report.

Faria GR, Eloy C, Preto JR, Costa EL, Almeida T, Barbosa J, Paiva ME, Sousa-Rodrigues J, Pimenta A - J Med Case Rep (2010)

Histology - nodal metastasis (Hematoxylin and eosin staining).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2984469&req=5

Figure 5: Histology - nodal metastasis (Hematoxylin and eosin staining).
Mentions: This allows us to classify the tumor as a carcinoma of the gastric antrum (AE1 AE3 and CAM5.2 positivity) with a glandular component, but predominantly epidermoid (approximately 80 percent). No neuroendocrine differentiation was observed (Cromogranin A and Sinaptophysinwere negative) and gastrointestinal stromal tumor (GIST) and melanoma were excluded (c-Kit, HMB-45 and S100 protein were negative). The tumor extended to her serosa with lymphatic and venous invasion, and presented with nodal and hepatic metastasis. The nodal (Figure 5) and hepatic (Figure 6) metastasis presented both cellular lines (squamous and glandular) but the majority was occupied by the squamous component.

Bottom Line: Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations.Adenosquamous gastric cancer is a rare diagnosis in western populations.The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

View Article: PubMed Central - HTML - PubMed

Affiliation: General Surgery Department, Hospital de São João/Faculty of Medicine at University of Porto, Alameda Prof, Hernâni Monteiro - Porto 4200-319, Portugal. dr.gilfaria@netcabo.pt.

ABSTRACT

Introduction: Most gastric tumors are adenocarcinomas. Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations. It constitutes less than one percent of all gastric carcinomas and its clinical presentation is the same as adenocarcinoma. It occurs more frequently in the proximal stomach, usually presents with muscular layer invasion and tends to be found in advanced stages at diagnosis, with a worse prognosis than adenocarcinoma.

Case presentation: We report the case of an 84-year-old Caucasian woman with an adenosquamous carcinoma extending to her serosa with lymphatic and venous invasion (T3N1M1). Nodal and hepatic metastasis presented with both cellular types, with dominance of the squamous component.

Conclusions: Adenosquamous gastric cancer is a rare diagnosis in western populations. We present the case of a woman with a very aggressive adenosquamous carcinoma with a preponderance of squamous cell component in the metastasis. Several origins have been proposed for this kind of carcinoma; either evolution from adenocarcinoma de-differentiation or stem cell origin might be possible. The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

No MeSH data available.


Related in: MedlinePlus