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4-(3-Methyl-anilino)-N-[N-(1-methyl-ethyl)carbamo-yl]pyridinium-3-sulfon-amidate (torasemide) methanol 0.25-solvate 0.25-hydrate.

Bartolucci G, Bruni B, Coran SA, Di Vaira M - Acta Crystallogr Sect E Struct Rep Online (2009)

Bottom Line: It is isomorphous with the previously reported nonsolvated T-II form of torasemide.The water mol-ecules contribute to the stability of the structure by participating in an extensive system of O-H⋯O hydrogen bonds; N-H⋯N and N-H⋯O hydrogen bonds are also present.Both asymmetric mol-ecules of torasemide form inversion dimers in the crystal.

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ABSTRACT
The title compound, C(16)H(20)N(4)O(3)S·0.25CH(4)O·0.25H(2)O, is a hydrate/methanol solvate of torasemide, a diuretic drug used in the treatment of hypertension. The asymmetric unit contains two torasemide mol-ecules and half-occupied methanol and water mol-ecules. It is isomorphous with the previously reported nonsolvated T-II form of torasemide. The water mol-ecules contribute to the stability of the structure by participating in an extensive system of O-H⋯O hydrogen bonds; N-H⋯N and N-H⋯O hydrogen bonds are also present. Both asymmetric mol-ecules of torasemide form inversion dimers in the crystal.

No MeSH data available.


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The arrangement of chains, parallel to the [01–1] direction, of hydrogen–bonded molecules in proximity of the bc face. A similar arrangement, however with the alternative [011] chain orientation, exists on the parallel flanking planes at a/2 distance from the one shown.
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Fap3: The arrangement of chains, parallel to the [01–1] direction, of hydrogen–bonded molecules in proximity of the bc face. A similar arrangement, however with the alternative [011] chain orientation, exists on the parallel flanking planes at a/2 distance from the one shown.


4-(3-Methyl-anilino)-N-[N-(1-methyl-ethyl)carbamo-yl]pyridinium-3-sulfon-amidate (torasemide) methanol 0.25-solvate 0.25-hydrate.

Bartolucci G, Bruni B, Coran SA, Di Vaira M - Acta Crystallogr Sect E Struct Rep Online (2009)

The arrangement of chains, parallel to the [01–1] direction, of hydrogen–bonded molecules in proximity of the bc face. A similar arrangement, however with the alternative [011] chain orientation, exists on the parallel flanking planes at a/2 distance from the one shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2977669&req=5

Fap3: The arrangement of chains, parallel to the [01–1] direction, of hydrogen–bonded molecules in proximity of the bc face. A similar arrangement, however with the alternative [011] chain orientation, exists on the parallel flanking planes at a/2 distance from the one shown.
Bottom Line: It is isomorphous with the previously reported nonsolvated T-II form of torasemide.The water mol-ecules contribute to the stability of the structure by participating in an extensive system of O-H⋯O hydrogen bonds; N-H⋯N and N-H⋯O hydrogen bonds are also present.Both asymmetric mol-ecules of torasemide form inversion dimers in the crystal.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
The title compound, C(16)H(20)N(4)O(3)S·0.25CH(4)O·0.25H(2)O, is a hydrate/methanol solvate of torasemide, a diuretic drug used in the treatment of hypertension. The asymmetric unit contains two torasemide mol-ecules and half-occupied methanol and water mol-ecules. It is isomorphous with the previously reported nonsolvated T-II form of torasemide. The water mol-ecules contribute to the stability of the structure by participating in an extensive system of O-H⋯O hydrogen bonds; N-H⋯N and N-H⋯O hydrogen bonds are also present. Both asymmetric mol-ecules of torasemide form inversion dimers in the crystal.

No MeSH data available.


Related in: MedlinePlus