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Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects.

Kim TI, Chung CP, Heo MS, Park YJ, Rhee SH - J Periodontal Implant Sci (2010)

Bottom Line: The equine particulate bone-inserted group showed significantly decreased values of probing depth and first bone contact compared to the negative control and collagen membrane alone groups at weeks 10, 16, and 24 (P < 0.05).Equine particulate bone showed significant differences in probing depth, first bone contact, new cementum length, newly formed bone area, and bone volume fraction values when compared to the negative control and collagen membrane alone groups.There were no significant differences between equine and bovine particulate bone substitutes in these parameters; therefore, we can conclude that equine particulate bone is equivalent to bovine bone for periodontal regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the periodontal wound healing effect of particulate equine bone mineral on canine alveolar bone defects.

Methods: Twelve adult male beagle dogs were used as study subjects. The mandibular second and fourth premolars were extracted prior to the experimental surgery, and the extraction sites were allowed to heal for 8 weeks. After periodontal probing, two-walled defects were created at the mesial and distal sides of the mandibular third premolars bilaterally, and the defects were filled with equine particulate bone with collagen membrane or bovine particulate bone with collagen membrane, or collagen membrane alone. The defects without any treatment served as negative controls. After probing depth measurement, animals were sacrificed at 10, 16, and 24 post-surgery weeks for micro-computed tomographic and histomorphometric analysis.

Results: The equine particulate bone-inserted group showed significantly decreased values of probing depth and first bone contact compared to the negative control and collagen membrane alone groups at weeks 10, 16, and 24 (P < 0.05). There were no significant differences in the new cementum length, newly-formed bone area, or newly-formed bone volume between equine particulate bone- and bovine particulate bone-inserted groups, both of which showed significantly increased values compared to the negative control and collagen membrane alone groups (P < 0.05).

Conclusions: Equine particulate bone showed significant differences in probing depth, first bone contact, new cementum length, newly formed bone area, and bone volume fraction values when compared to the negative control and collagen membrane alone groups. There were no significant differences between equine and bovine particulate bone substitutes in these parameters; therefore, we can conclude that equine particulate bone is equivalent to bovine bone for periodontal regeneration.

No MeSH data available.


Photomicrographs showing the defects at 10, 16, and 24 weeks. New cementum and bone formation was evident in both particulate bone substitute groups. (A) negative control group, (B) collagen membrane group, (C) bovine particulate bone group, and (D) equine particulate bone group (▴ new bone; ♦ new cementum; ⋆ bone substitutes).
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Figure 2: Photomicrographs showing the defects at 10, 16, and 24 weeks. New cementum and bone formation was evident in both particulate bone substitute groups. (A) negative control group, (B) collagen membrane group, (C) bovine particulate bone group, and (D) equine particulate bone group (▴ new bone; ♦ new cementum; ⋆ bone substitutes).

Mentions: The alveolar bone defects were mainly filled with fibrous tissues with little new bone formation in the negative control and collagen membrane alone groups compared to the bone substitute inserted groups (Fig. 2). The remaining collagen membrane was not detected in these histologic sections, so it had to have been completely resorbed during the healing period. New cementum formation was evident in both of the particulate bone-inserted groups compared to the control and collagen membrane alone groups.


Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects.

Kim TI, Chung CP, Heo MS, Park YJ, Rhee SH - J Periodontal Implant Sci (2010)

Photomicrographs showing the defects at 10, 16, and 24 weeks. New cementum and bone formation was evident in both particulate bone substitute groups. (A) negative control group, (B) collagen membrane group, (C) bovine particulate bone group, and (D) equine particulate bone group (▴ new bone; ♦ new cementum; ⋆ bone substitutes).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2967809&req=5

Figure 2: Photomicrographs showing the defects at 10, 16, and 24 weeks. New cementum and bone formation was evident in both particulate bone substitute groups. (A) negative control group, (B) collagen membrane group, (C) bovine particulate bone group, and (D) equine particulate bone group (▴ new bone; ♦ new cementum; ⋆ bone substitutes).
Mentions: The alveolar bone defects were mainly filled with fibrous tissues with little new bone formation in the negative control and collagen membrane alone groups compared to the bone substitute inserted groups (Fig. 2). The remaining collagen membrane was not detected in these histologic sections, so it had to have been completely resorbed during the healing period. New cementum formation was evident in both of the particulate bone-inserted groups compared to the control and collagen membrane alone groups.

Bottom Line: The equine particulate bone-inserted group showed significantly decreased values of probing depth and first bone contact compared to the negative control and collagen membrane alone groups at weeks 10, 16, and 24 (P < 0.05).Equine particulate bone showed significant differences in probing depth, first bone contact, new cementum length, newly formed bone area, and bone volume fraction values when compared to the negative control and collagen membrane alone groups.There were no significant differences between equine and bovine particulate bone substitutes in these parameters; therefore, we can conclude that equine particulate bone is equivalent to bovine bone for periodontal regeneration.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the periodontal wound healing effect of particulate equine bone mineral on canine alveolar bone defects.

Methods: Twelve adult male beagle dogs were used as study subjects. The mandibular second and fourth premolars were extracted prior to the experimental surgery, and the extraction sites were allowed to heal for 8 weeks. After periodontal probing, two-walled defects were created at the mesial and distal sides of the mandibular third premolars bilaterally, and the defects were filled with equine particulate bone with collagen membrane or bovine particulate bone with collagen membrane, or collagen membrane alone. The defects without any treatment served as negative controls. After probing depth measurement, animals were sacrificed at 10, 16, and 24 post-surgery weeks for micro-computed tomographic and histomorphometric analysis.

Results: The equine particulate bone-inserted group showed significantly decreased values of probing depth and first bone contact compared to the negative control and collagen membrane alone groups at weeks 10, 16, and 24 (P < 0.05). There were no significant differences in the new cementum length, newly-formed bone area, or newly-formed bone volume between equine particulate bone- and bovine particulate bone-inserted groups, both of which showed significantly increased values compared to the negative control and collagen membrane alone groups (P < 0.05).

Conclusions: Equine particulate bone showed significant differences in probing depth, first bone contact, new cementum length, newly formed bone area, and bone volume fraction values when compared to the negative control and collagen membrane alone groups. There were no significant differences between equine and bovine particulate bone substitutes in these parameters; therefore, we can conclude that equine particulate bone is equivalent to bovine bone for periodontal regeneration.

No MeSH data available.