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Impact of herpes zoster and post-herpetic neuralgia on patients' quality of life: a patient-reported outcomes survey.

Weinke T, Edte A, Schmitt S, Lukas K - Z Gesundh Wiss (2010)

Bottom Line: PHN was associated with significantly worse outcomes than HZ (all P < 0.05).Mean pain scores associated with PHN and HZ, respectively, were 7.1 and 6.2 (average) and 8.2 and 7.0 (worst).Pain and QoL outcomes were not significantly different between all patients versus those diagnosed during the previous 12 months or between patients aged 50-59 years versus ≥60 years.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: The impact of herpes zoster (HZ) and post-herpetic neuralgia (PHN) on patients' quality of life (QoL) is currently poorly documented. SUBJECTS AND METHODS: Telephone interviews in Germany identified patients ≥50 years old with painful HZ diagnosed during the previous 5 years. Bespoke questions evaluated previous HZ episodes. RESULTS: Of 11,009 respondents, 280 met the screening criteria, and 32 (11%) developed PHN. PHN was associated with significantly worse outcomes than HZ (all P < 0.05). Mean pain scores associated with PHN and HZ, respectively, were 7.1 and 6.2 (average) and 8.2 and 7.0 (worst). Many patients with PHN (91%) and HZ (73%) experienced problems with daily activities, including work, studies, housework, family and leisure activities. Mean pain interference scores in patients with PHN versus HZ were highest for sleep (6.5 versus 4.9), normal work (6.1 versus 4.4) and mood (5.9 versus 4.4). Most employed interviewees with PHN (70%) and HZ (64%) stopped work during the disease. Pain and QoL outcomes were not significantly different between all patients versus those diagnosed during the previous 12 months or between patients aged 50-59 years versus ≥60 years. CONCLUSIONS: HZ causes substantial pain, which seriously interferes with many aspects of daily life, particularly in patients with PHN.

No MeSH data available.


Related in: MedlinePlus

Proportion of patients whose HZ had a high (score 8–10), medium (score 4–7) and low (score 0–3) impact on overall QoL
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Fig2: Proportion of patients whose HZ had a high (score 8–10), medium (score 4–7) and low (score 0–3) impact on overall QoL

Mentions: The impact of HZ/PHN on patients’ overall QoL was considerable, with a mean affection score of 4.5 in all patients and 4.2 versus 6.1 in patients with HZ versus PHN, respectively (P < 0.05). Greater proportions of patients with PHN than HZ reported that their QoL was affected to a high level (35% versus 17%) or medium level (50% versus 39%) (Fig. 2).Fig. 2


Impact of herpes zoster and post-herpetic neuralgia on patients' quality of life: a patient-reported outcomes survey.

Weinke T, Edte A, Schmitt S, Lukas K - Z Gesundh Wiss (2010)

Proportion of patients whose HZ had a high (score 8–10), medium (score 4–7) and low (score 0–3) impact on overall QoL
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2967249&req=5

Fig2: Proportion of patients whose HZ had a high (score 8–10), medium (score 4–7) and low (score 0–3) impact on overall QoL
Mentions: The impact of HZ/PHN on patients’ overall QoL was considerable, with a mean affection score of 4.5 in all patients and 4.2 versus 6.1 in patients with HZ versus PHN, respectively (P < 0.05). Greater proportions of patients with PHN than HZ reported that their QoL was affected to a high level (35% versus 17%) or medium level (50% versus 39%) (Fig. 2).Fig. 2

Bottom Line: PHN was associated with significantly worse outcomes than HZ (all P < 0.05).Mean pain scores associated with PHN and HZ, respectively, were 7.1 and 6.2 (average) and 8.2 and 7.0 (worst).Pain and QoL outcomes were not significantly different between all patients versus those diagnosed during the previous 12 months or between patients aged 50-59 years versus ≥60 years.

View Article: PubMed Central - PubMed

ABSTRACT
BACKGROUND: The impact of herpes zoster (HZ) and post-herpetic neuralgia (PHN) on patients' quality of life (QoL) is currently poorly documented. SUBJECTS AND METHODS: Telephone interviews in Germany identified patients ≥50 years old with painful HZ diagnosed during the previous 5 years. Bespoke questions evaluated previous HZ episodes. RESULTS: Of 11,009 respondents, 280 met the screening criteria, and 32 (11%) developed PHN. PHN was associated with significantly worse outcomes than HZ (all P < 0.05). Mean pain scores associated with PHN and HZ, respectively, were 7.1 and 6.2 (average) and 8.2 and 7.0 (worst). Many patients with PHN (91%) and HZ (73%) experienced problems with daily activities, including work, studies, housework, family and leisure activities. Mean pain interference scores in patients with PHN versus HZ were highest for sleep (6.5 versus 4.9), normal work (6.1 versus 4.4) and mood (5.9 versus 4.4). Most employed interviewees with PHN (70%) and HZ (64%) stopped work during the disease. Pain and QoL outcomes were not significantly different between all patients versus those diagnosed during the previous 12 months or between patients aged 50-59 years versus ≥60 years. CONCLUSIONS: HZ causes substantial pain, which seriously interferes with many aspects of daily life, particularly in patients with PHN.

No MeSH data available.


Related in: MedlinePlus