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Imaging of perineural spread in head and neck tumours.

Ong CK, Chong VF - Cancer Imaging (2010)

Bottom Line: Perineural tumour spread refers to a contiguous neoplastic extension along a nerve.This article focuses on the imaging features of perineural spread of head and neck tumours.The important potential perineural pathways and the possible underlying pathogenesis of this phenomenon are also reviewed.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Imaging, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. cheng_kang_ong@nuhs.edu.sg

ABSTRACT
Perineural tumour spread refers to a contiguous neoplastic extension along a nerve. As it may be clinically silent, imaging plays a pivotal role in the evaluation and delineation of perineural infiltration in head and neck malignancies, which in turn affects treatment planning. This article focuses on the imaging features of perineural spread of head and neck tumours. The important potential perineural pathways and the possible underlying pathogenesis of this phenomenon are also reviewed.

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Centrifugal perineural spread. (a) Axial contrast-enhanced fat-suppressed T1-weighted image shows a meningioma arising from the lateral wall of the left cavernous sinus (black arrow). No centripetal perineural spread to the cisternal segment of the left trigeminal nerve is seen (white arrow). (b) Axial and (c) coronal contrast-enhanced fat-suppressed T1-weighted images show centrifugal perineural tumour spread along the mandibular nerve through the foramen ovale (arrow). (d) Coronal contrast-enhanced fat-suppressed T1-weighted image shows centrifugal perineural tumour spread along the maxillary nerve through the foramen rotundum (arrow). (e) Axial T1-weighted image shows effacement of the normal fat tissue within the left pterygopalatine fossa by the perineural tumour along the maxillary nerve (arrow).
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Figure 3: Centrifugal perineural spread. (a) Axial contrast-enhanced fat-suppressed T1-weighted image shows a meningioma arising from the lateral wall of the left cavernous sinus (black arrow). No centripetal perineural spread to the cisternal segment of the left trigeminal nerve is seen (white arrow). (b) Axial and (c) coronal contrast-enhanced fat-suppressed T1-weighted images show centrifugal perineural tumour spread along the mandibular nerve through the foramen ovale (arrow). (d) Coronal contrast-enhanced fat-suppressed T1-weighted image shows centrifugal perineural tumour spread along the maxillary nerve through the foramen rotundum (arrow). (e) Axial T1-weighted image shows effacement of the normal fat tissue within the left pterygopalatine fossa by the perineural tumour along the maxillary nerve (arrow).

Mentions: Perineural tumours typically extend centripetally toward the brain, although centrifugal spread is not uncommonly seen (Figs. 2 and 3).Figure 2


Imaging of perineural spread in head and neck tumours.

Ong CK, Chong VF - Cancer Imaging (2010)

Centrifugal perineural spread. (a) Axial contrast-enhanced fat-suppressed T1-weighted image shows a meningioma arising from the lateral wall of the left cavernous sinus (black arrow). No centripetal perineural spread to the cisternal segment of the left trigeminal nerve is seen (white arrow). (b) Axial and (c) coronal contrast-enhanced fat-suppressed T1-weighted images show centrifugal perineural tumour spread along the mandibular nerve through the foramen ovale (arrow). (d) Coronal contrast-enhanced fat-suppressed T1-weighted image shows centrifugal perineural tumour spread along the maxillary nerve through the foramen rotundum (arrow). (e) Axial T1-weighted image shows effacement of the normal fat tissue within the left pterygopalatine fossa by the perineural tumour along the maxillary nerve (arrow).
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2967145&req=5

Figure 3: Centrifugal perineural spread. (a) Axial contrast-enhanced fat-suppressed T1-weighted image shows a meningioma arising from the lateral wall of the left cavernous sinus (black arrow). No centripetal perineural spread to the cisternal segment of the left trigeminal nerve is seen (white arrow). (b) Axial and (c) coronal contrast-enhanced fat-suppressed T1-weighted images show centrifugal perineural tumour spread along the mandibular nerve through the foramen ovale (arrow). (d) Coronal contrast-enhanced fat-suppressed T1-weighted image shows centrifugal perineural tumour spread along the maxillary nerve through the foramen rotundum (arrow). (e) Axial T1-weighted image shows effacement of the normal fat tissue within the left pterygopalatine fossa by the perineural tumour along the maxillary nerve (arrow).
Mentions: Perineural tumours typically extend centripetally toward the brain, although centrifugal spread is not uncommonly seen (Figs. 2 and 3).Figure 2

Bottom Line: Perineural tumour spread refers to a contiguous neoplastic extension along a nerve.This article focuses on the imaging features of perineural spread of head and neck tumours.The important potential perineural pathways and the possible underlying pathogenesis of this phenomenon are also reviewed.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Imaging, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. cheng_kang_ong@nuhs.edu.sg

ABSTRACT
Perineural tumour spread refers to a contiguous neoplastic extension along a nerve. As it may be clinically silent, imaging plays a pivotal role in the evaluation and delineation of perineural infiltration in head and neck malignancies, which in turn affects treatment planning. This article focuses on the imaging features of perineural spread of head and neck tumours. The important potential perineural pathways and the possible underlying pathogenesis of this phenomenon are also reviewed.

Show MeSH
Related in: MedlinePlus