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MicroRNA in lung cancer.

Lin PY, Yu SL, Yang PC - Br. J. Cancer (2010)

Bottom Line: MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators.Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer.In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

ABSTRACT
MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

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Related in: MedlinePlus

Stratification of lung cancer based on microRNA information. NSCLC, non-small-cell lung cancer.
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Related In: Results  -  Collection


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fig1: Stratification of lung cancer based on microRNA information. NSCLC, non-small-cell lung cancer.

Mentions: In this review, we briefly describe the biogenesis of miRNAs, their roles in lung cancer pathogenesis, and their potential use in NSCLC subgroup classification, risk stratification, and therapy. The stratification of lung cancer based on miRNA information is illustrated in Figure 1.


MicroRNA in lung cancer.

Lin PY, Yu SL, Yang PC - Br. J. Cancer (2010)

Stratification of lung cancer based on microRNA information. NSCLC, non-small-cell lung cancer.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2967070&req=5

fig1: Stratification of lung cancer based on microRNA information. NSCLC, non-small-cell lung cancer.
Mentions: In this review, we briefly describe the biogenesis of miRNAs, their roles in lung cancer pathogenesis, and their potential use in NSCLC subgroup classification, risk stratification, and therapy. The stratification of lung cancer based on miRNA information is illustrated in Figure 1.

Bottom Line: MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators.Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer.In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

ABSTRACT
MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

Show MeSH
Related in: MedlinePlus