Limits...
Short-term health-related quality of life and symptom control with docetaxel, cisplatin, 5-fluorouracil and cisplatin (TPF), 5-fluorouracil (PF) for induction in unresectable locoregionally advanced head and neck cancer patients (EORTC 24971/TAX 323).

van Herpen CM, Mauer ME, Mesia R, Degardin M, Jelic S, Coens C, Betka J, Bernier J, Remenar E, Stewart JS, Preiss JH, van den Weyngaert D, Bottomley A, Vermorken JB, EORTC Head and Neck Gro - Br. J. Cancer (2010)

Bottom Line: There was a trend towards improved global HRQOL during the treatment period.At 6 months after the end of RT, global HRQOL was higher in the TPF arm than in the PF arm, but the low compliance does not allow to draw definitive conclusions.Swallowing and coughing problems decreased more in the TPF arm than in the PF arm at the end of cycle 2, but to a limited extent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Radboud University Nijmegen Medical Centre, 452, PO Box 9101, 6500 HB Nijmegen, The Netherlands. C.vanherpen@onco.umcn.nl

ABSTRACT

Background: The EORTC 24971/TAX 323, a phase III study of 358 patients with unresectable locoregionally advanced squamous cell carcinoma of the head and neck, showed an improved progression-free and overall survival (OS) with less toxicity when docetaxel (T) was added to cisplatin and 5-fluorouracil (PF) for induction and given before radiotherapy (RT). The impact of the addition of docetaxel on patients' health-related quality of life (HRQOL) and symptoms was investigated.

Methods: HRQOL was assessed at baseline, at end of cycle 2, and 4, 6, and 9 months after completion of RT using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQ-C30) and the EORTC QLQ Head and Neck Cancer-Specific Module (EORTC QLQ-H&N35). The primary HRQOL scale was global HRQOL per protocol.

Results: Compliance to HRQOL assessments was 97% at baseline, but dropped to 54% by 6 months. Data were analysed up to 6 months. There was a trend towards improved global HRQOL during the treatment period. At 6 months after the end of RT, global HRQOL was higher in the TPF arm than in the PF arm, but the low compliance does not allow to draw definitive conclusions. Swallowing and coughing problems decreased more in the TPF arm than in the PF arm at the end of cycle 2, but to a limited extent.

Conclusion: Induction chemotherapy with TPF before RT not only improves survival and reduces toxicity compared with PF but also seems to improve global HRQOL in a more sustainable manner.

Show MeSH

Related in: MedlinePlus

Evolution of mean scores in other non-selected scales over time.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2967049&req=5

fig3: Evolution of mean scores in other non-selected scales over time.

Mentions: An exploratory analysis of the non-preselected remaining HRQOL scales was performed. An increase in loss of appetite was noticed in the PF arm, whereas it was stable in the TPF arm (mean difference of 10.3; P=0.013 at the end of cycle 4); there was more weight loss (mean difference of 17.1; P=0.059) and less weight gain (mean difference of 25.1; P=0.0007) in the PF arm at the end of cycle 4 (Figure 3). Except for appetite loss, the measures were similar in the two treatment arms at 6 months after RT. For all other scales, there were no statistically significant treatment differences at any time point.


Short-term health-related quality of life and symptom control with docetaxel, cisplatin, 5-fluorouracil and cisplatin (TPF), 5-fluorouracil (PF) for induction in unresectable locoregionally advanced head and neck cancer patients (EORTC 24971/TAX 323).

van Herpen CM, Mauer ME, Mesia R, Degardin M, Jelic S, Coens C, Betka J, Bernier J, Remenar E, Stewart JS, Preiss JH, van den Weyngaert D, Bottomley A, Vermorken JB, EORTC Head and Neck Gro - Br. J. Cancer (2010)

Evolution of mean scores in other non-selected scales over time.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2967049&req=5

fig3: Evolution of mean scores in other non-selected scales over time.
Mentions: An exploratory analysis of the non-preselected remaining HRQOL scales was performed. An increase in loss of appetite was noticed in the PF arm, whereas it was stable in the TPF arm (mean difference of 10.3; P=0.013 at the end of cycle 4); there was more weight loss (mean difference of 17.1; P=0.059) and less weight gain (mean difference of 25.1; P=0.0007) in the PF arm at the end of cycle 4 (Figure 3). Except for appetite loss, the measures were similar in the two treatment arms at 6 months after RT. For all other scales, there were no statistically significant treatment differences at any time point.

Bottom Line: There was a trend towards improved global HRQOL during the treatment period.At 6 months after the end of RT, global HRQOL was higher in the TPF arm than in the PF arm, but the low compliance does not allow to draw definitive conclusions.Swallowing and coughing problems decreased more in the TPF arm than in the PF arm at the end of cycle 2, but to a limited extent.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Radboud University Nijmegen Medical Centre, 452, PO Box 9101, 6500 HB Nijmegen, The Netherlands. C.vanherpen@onco.umcn.nl

ABSTRACT

Background: The EORTC 24971/TAX 323, a phase III study of 358 patients with unresectable locoregionally advanced squamous cell carcinoma of the head and neck, showed an improved progression-free and overall survival (OS) with less toxicity when docetaxel (T) was added to cisplatin and 5-fluorouracil (PF) for induction and given before radiotherapy (RT). The impact of the addition of docetaxel on patients' health-related quality of life (HRQOL) and symptoms was investigated.

Methods: HRQOL was assessed at baseline, at end of cycle 2, and 4, 6, and 9 months after completion of RT using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQ-C30) and the EORTC QLQ Head and Neck Cancer-Specific Module (EORTC QLQ-H&N35). The primary HRQOL scale was global HRQOL per protocol.

Results: Compliance to HRQOL assessments was 97% at baseline, but dropped to 54% by 6 months. Data were analysed up to 6 months. There was a trend towards improved global HRQOL during the treatment period. At 6 months after the end of RT, global HRQOL was higher in the TPF arm than in the PF arm, but the low compliance does not allow to draw definitive conclusions. Swallowing and coughing problems decreased more in the TPF arm than in the PF arm at the end of cycle 2, but to a limited extent.

Conclusion: Induction chemotherapy with TPF before RT not only improves survival and reduces toxicity compared with PF but also seems to improve global HRQOL in a more sustainable manner.

Show MeSH
Related in: MedlinePlus