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Lymphoepithelioma-like carcinoma of the urinary bladder.

Yun HK, Yun SI, Lee YH, Kang KM, Kwak EK, Kim JS, Cho SR, Kwon JB - J. Korean Med. Sci. (2010)

Bottom Line: On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells.The case was followed-up for 8 months without recurrence.This is the first report of a LELCA case in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Daegu Fatima Hospital, Daegu, Korea.

ABSTRACT
A 78-yr-old woman presented with gross hematuria for 2 weeks. On cystoscopy, a frond-like mass was observed at the bladder trigone. Transurethral resection of bladder tumor was performed for the mass. Histopathological findings showed that 90% of lesions were lymphoepithelioma-like carcinoma (LELCA) and a few lesions were non-invasive transitional cell carcinoma. On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells. The case was followed-up for 8 months without recurrence. This is the first report of a LELCA case in Korea.

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Related in: MedlinePlus

Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.
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Figure 3: Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.

Mentions: On immunohistochemical staining, tumor cells were positive for cytokeratin 7 but were negative for cytokeratin 20 (Fig. 3). The infiltrated lymphocytes were composed of abundant CD3 positive T cells and CD20 positive B cells. For leukocyte common antigen (LCA), lymphoid cells were positive but tumor cells were negative (Fig. 4). In situ hybridization for Epstein-Barr virus was negative.


Lymphoepithelioma-like carcinoma of the urinary bladder.

Yun HK, Yun SI, Lee YH, Kang KM, Kwak EK, Kim JS, Cho SR, Kwon JB - J. Korean Med. Sci. (2010)

Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2967009&req=5

Figure 3: Cytokerain staining. (A) Immunochemical staining with antibodies against cytokeratin 7 is positive. (B) Negative immunochemical staining with antibodies against cytokeratin 20.
Mentions: On immunohistochemical staining, tumor cells were positive for cytokeratin 7 but were negative for cytokeratin 20 (Fig. 3). The infiltrated lymphocytes were composed of abundant CD3 positive T cells and CD20 positive B cells. For leukocyte common antigen (LCA), lymphoid cells were positive but tumor cells were negative (Fig. 4). In situ hybridization for Epstein-Barr virus was negative.

Bottom Line: On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells.The case was followed-up for 8 months without recurrence.This is the first report of a LELCA case in Korea.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Daegu Fatima Hospital, Daegu, Korea.

ABSTRACT
A 78-yr-old woman presented with gross hematuria for 2 weeks. On cystoscopy, a frond-like mass was observed at the bladder trigone. Transurethral resection of bladder tumor was performed for the mass. Histopathological findings showed that 90% of lesions were lymphoepithelioma-like carcinoma (LELCA) and a few lesions were non-invasive transitional cell carcinoma. On microscopy, syncytial growth pattern and indistinct cytoplasmic borders were observed with the severe infiltration of lymphoid cells. The case was followed-up for 8 months without recurrence. This is the first report of a LELCA case in Korea.

Show MeSH
Related in: MedlinePlus