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Cardiovascular diseases after kidney transplantation in Korea.

Jeong JC, Ro H, Hwang YH, Lee HK, Ha J, Ahn C, Yang J - J. Korean Med. Sci. (2010)

Bottom Line: CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease.Mean age of recipients was 40.0±11.8 yr.Mean duration of follow-up was 72±39 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430 adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient's age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95% CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665] respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.

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Differences in the cumulative incidence of cardiovascular disease according to diabetes status. Median time interval from transplantation to CVD was significantly different between groups. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001, Log rank test).
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Figure 2: Differences in the cumulative incidence of cardiovascular disease according to diabetes status. Median time interval from transplantation to CVD was significantly different between groups. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001, Log rank test).

Mentions: Fig. 2 is a Kaplan-Meier curve which depicts occurrence of cardiovascular disease according to diabetes status (diabetes before transplantation group, PTDM group and non-diabetes group). In Fig. 2, CVD tends to occur in the later period in PTDM group. Median time interval from transplantation to CVD was 122 months in PTDM group. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001) In addition, CVD also tends to occur in the later period in PTDM group compared with diabetes mellitus group (P=0.025).


Cardiovascular diseases after kidney transplantation in Korea.

Jeong JC, Ro H, Hwang YH, Lee HK, Ha J, Ahn C, Yang J - J. Korean Med. Sci. (2010)

Differences in the cumulative incidence of cardiovascular disease according to diabetes status. Median time interval from transplantation to CVD was significantly different between groups. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001, Log rank test).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2966995&req=5

Figure 2: Differences in the cumulative incidence of cardiovascular disease according to diabetes status. Median time interval from transplantation to CVD was significantly different between groups. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001, Log rank test).
Mentions: Fig. 2 is a Kaplan-Meier curve which depicts occurrence of cardiovascular disease according to diabetes status (diabetes before transplantation group, PTDM group and non-diabetes group). In Fig. 2, CVD tends to occur in the later period in PTDM group. Median time interval from transplantation to CVD was 122 months in PTDM group. (Diabetes vs PTDM vs non-diabetes, 14 months: 122 months: 40 months, P<0.001) In addition, CVD also tends to occur in the later period in PTDM group compared with diabetes mellitus group (P=0.025).

Bottom Line: CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease.Mean age of recipients was 40.0±11.8 yr.Mean duration of follow-up was 72±39 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430 adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient's age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95% CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665] respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.

Show MeSH
Related in: MedlinePlus