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Cardiovascular diseases after kidney transplantation in Korea.

Jeong JC, Ro H, Hwang YH, Lee HK, Ha J, Ahn C, Yang J - J. Korean Med. Sci. (2010)

Bottom Line: CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease.Mean age of recipients was 40.0±11.8 yr.Mean duration of follow-up was 72±39 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430 adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient's age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95% CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665] respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.

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Related in: MedlinePlus

The cumulative incidence of cardiovascular disease after renal transplantation. The estimated percentage equals 2.4% after 5 yr, 5.4% after 10 yr and 11.4% after 12 yr.
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Figure 1: The cumulative incidence of cardiovascular disease after renal transplantation. The estimated percentage equals 2.4% after 5 yr, 5.4% after 10 yr and 11.4% after 12 yr.

Mentions: CVD occurred in 16 patients during follow up. The mean duration of follow up was 72±39 months (range, 0-156 months). Fig. 1 shows the cumulative incidence of CVD after renal transplantation: 2.4% at 5 yr, 5.4% at 10 yr, and 11.4% at 12 yr. Table 1 describes detailed information of CVD. CVD occurred in various time periods (range 0-131 months). MI occurred in five patients and two of them died. The other mortality occurred in a PVD patient due to an infection.


Cardiovascular diseases after kidney transplantation in Korea.

Jeong JC, Ro H, Hwang YH, Lee HK, Ha J, Ahn C, Yang J - J. Korean Med. Sci. (2010)

The cumulative incidence of cardiovascular disease after renal transplantation. The estimated percentage equals 2.4% after 5 yr, 5.4% after 10 yr and 11.4% after 12 yr.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2966995&req=5

Figure 1: The cumulative incidence of cardiovascular disease after renal transplantation. The estimated percentage equals 2.4% after 5 yr, 5.4% after 10 yr and 11.4% after 12 yr.
Mentions: CVD occurred in 16 patients during follow up. The mean duration of follow up was 72±39 months (range, 0-156 months). Fig. 1 shows the cumulative incidence of CVD after renal transplantation: 2.4% at 5 yr, 5.4% at 10 yr, and 11.4% at 12 yr. Table 1 describes detailed information of CVD. CVD occurred in various time periods (range 0-131 months). MI occurred in five patients and two of them died. The other mortality occurred in a PVD patient due to an infection.

Bottom Line: CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease.Mean age of recipients was 40.0±11.8 yr.Mean duration of follow-up was 72±39 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT
Cardiovascular disease (CVD) is the leading cause of death in renal allograft recipients with functioning graft. Our study aimed to determine the incidence and the risk factors of cardiovascular disease after renal transplantation in Korea. We retrospectively analyzed 430 adult recipients who underwent kidney transplantation between January 1997 and February 2007. CVD was defined as a composite outcome of ischemic heart disease, cerebrovascular accident and peripheral vascular disease. Mean age of recipients was 40.0±11.8 yr. Mean duration of follow-up was 72±39 months. The cumulative incidence of CVD after renal transplantation was 2.4% at 5 yr, 5.4% at 10 yr and 11.4% at 12 yr. Multivariate analysis revealed that recipient's age, diabetes mellitus and duration of dialysis before transplantation were associated with post-transplant CVD (hazard ratio 1.843 [95% CI, 1.005-3.381], 3.846 [95% CI, 1.025-14.432] and 3.394 [95% CI, 1.728-6.665] respectively). In conclusion, old age, duration of dialysis and diabetes mellitus are important risk factors for post-transplant CVD, although the incidence of post-renal transplant CVD is lower in Korea than that in western countries.

Show MeSH
Related in: MedlinePlus