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A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S - J Clin Biochem Nutr (2010)

Bottom Line: It is beneficial to seek scientific basis for the effects of functional foods.Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine.Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.

ABSTRACT
It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the antioxidative effect of a beverage obtained via citric acid fermentation of black soybean (BBS), using a rat model of renal oxidative injury induced by a renal carcinogen, ferric nitrilotriacetate. BBS (10 ml/kg) was orally administered 30 min before ferric nitrilotriacetate treatment. Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine. Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats. Elevation of serum creatinine and urea nitrogen was significantly suppressed in the BBS-pretreated rats. These data suggest that dietary intake of BBS is useful for the prevention of renal tubular oxidative damage mediate by iron, and warrant further investigation.

No MeSH data available.


Related in: MedlinePlus

Activities of renal antioxidative enzymes 24 h after Fe-NTA administration. Representative results of antioxidative enzymes are shown. (A) Catalase, (B) GSH Peroxidase, (C) GSH Reductase. Protective effects of BBS pretreatment on Fe-NTA-induced renal oxidative damage were observed (ANOVA, p<0.0001 for A–C; #p<0.05 vs untreated; *p<0.05 and ***p<0.001 vs Fe-NTA alone).
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Figure 4: Activities of renal antioxidative enzymes 24 h after Fe-NTA administration. Representative results of antioxidative enzymes are shown. (A) Catalase, (B) GSH Peroxidase, (C) GSH Reductase. Protective effects of BBS pretreatment on Fe-NTA-induced renal oxidative damage were observed (ANOVA, p<0.0001 for A–C; #p<0.05 vs untreated; *p<0.05 and ***p<0.001 vs Fe-NTA alone).

Mentions: Activities of all the antioxidative enzymes were decreased 4 h after Fe-NTA treatment, and BBS pretreatment prevented this decrease (Fig. 3). The same tendency was observed in many of the representative enzymes 24 h after Fe-NTA treatment (Fig. 4).


A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S - J Clin Biochem Nutr (2010)

Activities of renal antioxidative enzymes 24 h after Fe-NTA administration. Representative results of antioxidative enzymes are shown. (A) Catalase, (B) GSH Peroxidase, (C) GSH Reductase. Protective effects of BBS pretreatment on Fe-NTA-induced renal oxidative damage were observed (ANOVA, p<0.0001 for A–C; #p<0.05 vs untreated; *p<0.05 and ***p<0.001 vs Fe-NTA alone).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2966929&req=5

Figure 4: Activities of renal antioxidative enzymes 24 h after Fe-NTA administration. Representative results of antioxidative enzymes are shown. (A) Catalase, (B) GSH Peroxidase, (C) GSH Reductase. Protective effects of BBS pretreatment on Fe-NTA-induced renal oxidative damage were observed (ANOVA, p<0.0001 for A–C; #p<0.05 vs untreated; *p<0.05 and ***p<0.001 vs Fe-NTA alone).
Mentions: Activities of all the antioxidative enzymes were decreased 4 h after Fe-NTA treatment, and BBS pretreatment prevented this decrease (Fig. 3). The same tendency was observed in many of the representative enzymes 24 h after Fe-NTA treatment (Fig. 4).

Bottom Line: It is beneficial to seek scientific basis for the effects of functional foods.Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine.Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.

ABSTRACT
It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the antioxidative effect of a beverage obtained via citric acid fermentation of black soybean (BBS), using a rat model of renal oxidative injury induced by a renal carcinogen, ferric nitrilotriacetate. BBS (10 ml/kg) was orally administered 30 min before ferric nitrilotriacetate treatment. Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine. Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats. Elevation of serum creatinine and urea nitrogen was significantly suppressed in the BBS-pretreated rats. These data suggest that dietary intake of BBS is useful for the prevention of renal tubular oxidative damage mediate by iron, and warrant further investigation.

No MeSH data available.


Related in: MedlinePlus