Limits...
A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S - J Clin Biochem Nutr (2010)

Bottom Line: It is beneficial to seek scientific basis for the effects of functional foods.Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine.Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.

ABSTRACT
It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the antioxidative effect of a beverage obtained via citric acid fermentation of black soybean (BBS), using a rat model of renal oxidative injury induced by a renal carcinogen, ferric nitrilotriacetate. BBS (10 ml/kg) was orally administered 30 min before ferric nitrilotriacetate treatment. Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine. Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats. Elevation of serum creatinine and urea nitrogen was significantly suppressed in the BBS-pretreated rats. These data suggest that dietary intake of BBS is useful for the prevention of renal tubular oxidative damage mediate by iron, and warrant further investigation.

No MeSH data available.


Related in: MedlinePlus

Renal TBA-reactive substances 1 h after intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA). Prior intake of beverage containing fermented black soybean (BBS) decreased TBA-reactive substances. Refer to text for details (ANOVA, p = 0.0001; #p<0.05 vs untreated; *p<0.05 vs Fe-NTA alone).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2966929&req=5

Figure 1: Renal TBA-reactive substances 1 h after intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA). Prior intake of beverage containing fermented black soybean (BBS) decreased TBA-reactive substances. Refer to text for details (ANOVA, p = 0.0001; #p<0.05 vs untreated; *p<0.05 vs Fe-NTA alone).

Mentions: TBARS was elevated 1 h after Fe-NTA treatment in comparison with untreated animals. This elevation was significantly suppressed by BBS pretreatment (Fig. 1).


A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, Toyokuni S, Okada S - J Clin Biochem Nutr (2010)

Renal TBA-reactive substances 1 h after intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA). Prior intake of beverage containing fermented black soybean (BBS) decreased TBA-reactive substances. Refer to text for details (ANOVA, p = 0.0001; #p<0.05 vs untreated; *p<0.05 vs Fe-NTA alone).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2966929&req=5

Figure 1: Renal TBA-reactive substances 1 h after intraperitoneal injection of ferric nitrilotriacetate (Fe-NTA). Prior intake of beverage containing fermented black soybean (BBS) decreased TBA-reactive substances. Refer to text for details (ANOVA, p = 0.0001; #p<0.05 vs untreated; *p<0.05 vs Fe-NTA alone).
Mentions: TBARS was elevated 1 h after Fe-NTA treatment in comparison with untreated animals. This elevation was significantly suppressed by BBS pretreatment (Fig. 1).

Bottom Line: It is beneficial to seek scientific basis for the effects of functional foods.Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine.Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.

ABSTRACT
It is beneficial to seek scientific basis for the effects of functional foods. Natural pigments derived from plants are widely known as possible antioxidants. Black soybean contains a larger amount of anthocyanins than regular soybean. Here we studied the antioxidative effect of a beverage obtained via citric acid fermentation of black soybean (BBS), using a rat model of renal oxidative injury induced by a renal carcinogen, ferric nitrilotriacetate. BBS (10 ml/kg) was orally administered 30 min before ferric nitrilotriacetate treatment. Renal lipid peroxidation was significantly suppressed in the BBS-pretreated animals concomitant with decrease in 4-hydroxy-2-nonenal-modified proteins and 8-hydroxy-2'-deoxyguanosine. Maintenance of renal activities of antioxidative enzymes including catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase and quinone reductase was significantly better in the BBS-pretreated rats. Elevation of serum creatinine and urea nitrogen was significantly suppressed in the BBS-pretreated rats. These data suggest that dietary intake of BBS is useful for the prevention of renal tubular oxidative damage mediate by iron, and warrant further investigation.

No MeSH data available.


Related in: MedlinePlus