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Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women.

Yelumalai S, Muniandy S, Zawiah Omar S, Qvist R - J Clin Biochem Nutr (2010)

Bottom Line: Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN).PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls.These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstretics & Gynaecology, University of Malaya Medical Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.

No MeSH data available.


Related in: MedlinePlus

Box plot represents angiogenic factors concentration in control (a), hypertension (PIH) (b) and preeclampsia (PE) (c), at three different gestational ages, [mid pregnancy (EP, 24–28 weeks), late pregnancy (LP, 32–36 weeks) and postpartum (PN, 6 weeks after delivery)]. *, **p<0.05 as compared to control groups, ***p<0.001 as compared to control groups.
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Figure 2: Box plot represents angiogenic factors concentration in control (a), hypertension (PIH) (b) and preeclampsia (PE) (c), at three different gestational ages, [mid pregnancy (EP, 24–28 weeks), late pregnancy (LP, 32–36 weeks) and postpartum (PN, 6 weeks after delivery)]. *, **p<0.05 as compared to control groups, ***p<0.001 as compared to control groups.

Mentions: Fig. 1 (b) and (c) shows the concentration of PIGF and VEGF respectively in the three groups at three gestational ages. The levels of the pro-angiogenic factors (PIGF and VEGF) were inversely related to sFlt-1 levels in PE, PIH and Controls. Postpartum VEGF values were found to be approximately equivalent between PE, PIH and Controls. Imbalance in the levels of pro- and anti-angiogenic factors in the three groups at three gestational ages is summarized in Fig. 2 (a–c). In the control group (Fig. 2a), it is evident that PIGF levels are persistantly higher than sFlt-1 levels. However, in the PIH and PE groups, higher sFl-1 persisted throughout pregnancy. We also analyzed the ratio of log [sFlt-1/PIGF] in the maternal plasma of the preeclampsia patients and controls. The plasma log [sFlt-1/PIGF] ratio was significantly higher in the preeclampsia subjects than in controls (Fig. 3).


Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women.

Yelumalai S, Muniandy S, Zawiah Omar S, Qvist R - J Clin Biochem Nutr (2010)

Box plot represents angiogenic factors concentration in control (a), hypertension (PIH) (b) and preeclampsia (PE) (c), at three different gestational ages, [mid pregnancy (EP, 24–28 weeks), late pregnancy (LP, 32–36 weeks) and postpartum (PN, 6 weeks after delivery)]. *, **p<0.05 as compared to control groups, ***p<0.001 as compared to control groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2966928&req=5

Figure 2: Box plot represents angiogenic factors concentration in control (a), hypertension (PIH) (b) and preeclampsia (PE) (c), at three different gestational ages, [mid pregnancy (EP, 24–28 weeks), late pregnancy (LP, 32–36 weeks) and postpartum (PN, 6 weeks after delivery)]. *, **p<0.05 as compared to control groups, ***p<0.001 as compared to control groups.
Mentions: Fig. 1 (b) and (c) shows the concentration of PIGF and VEGF respectively in the three groups at three gestational ages. The levels of the pro-angiogenic factors (PIGF and VEGF) were inversely related to sFlt-1 levels in PE, PIH and Controls. Postpartum VEGF values were found to be approximately equivalent between PE, PIH and Controls. Imbalance in the levels of pro- and anti-angiogenic factors in the three groups at three gestational ages is summarized in Fig. 2 (a–c). In the control group (Fig. 2a), it is evident that PIGF levels are persistantly higher than sFlt-1 levels. However, in the PIH and PE groups, higher sFl-1 persisted throughout pregnancy. We also analyzed the ratio of log [sFlt-1/PIGF] in the maternal plasma of the preeclampsia patients and controls. The plasma log [sFlt-1/PIGF] ratio was significantly higher in the preeclampsia subjects than in controls (Fig. 3).

Bottom Line: Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN).PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls.These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstretics & Gynaecology, University of Malaya Medical Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.

No MeSH data available.


Related in: MedlinePlus