Limits...
Effect of remifentanil on consumption of sevoflurane in entropy monitored general anesthesia.

Kim HT, Heo HE, Kwon YE, Lee MJ - Korean J Anesthesiol (2010)

Bottom Line: ET was significantly lower in the R group than the S group.There were no significant differences in entropy value between R and S groups.Entropy monitored titration of sevoflurane with remifentanil administration decreased ET with stable hemodynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju, Korea.

ABSTRACT

Background: Monitoring of anesthetic depth is important for successful general anesthesia. It is well known that entropy or BIS monitoring assisted titration of anesthetic drugs decreases their consumption. This study evaluated the effect of remifentanil on consumption of sevoflurane during entropy monitored general anesthesia.

Methods: Patients were randomly assigned to two groups. The R group was administered 0.1 µg/kg/min of remifentanil and inhaled sevoflurane, while the S group was administered only inhaled sevoflurane. Anesthesia was maintained using sevoflurane with nitrous oxide, and entropy was monitored. In both groups, the concentration of sevoflurane was adjusted to keep the state entropy (SE) value between 40 and 60. End-tidal sevoflurane concentration (ET), entropy value, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 5 minute intervals, during a 25 minute period after intubation, skin suture and the end of surgery.

Results: ET was significantly lower in the R group than the S group. There were no significant differences in entropy value between R and S groups.

Conclusions: Entropy monitored titration of sevoflurane with remifentanil administration decreased ET with stable hemodynamics.

No MeSH data available.


Related in: MedlinePlus

Change of heart rate. Values are expressed as mean ± SD. Group S: group received normal saline. Group R: group received remifentanil (0.1 µg/kg/min). HR0-25: heart rate at 0-25 minute after intubation, HRss: heart rate at skin suture, HRend: heart rate at end of surgery. *P < 0.05 compared with HR0. †P < 0.05 compared with Group S.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2966703&req=5

Figure 6: Change of heart rate. Values are expressed as mean ± SD. Group S: group received normal saline. Group R: group received remifentanil (0.1 µg/kg/min). HR0-25: heart rate at 0-25 minute after intubation, HRss: heart rate at skin suture, HRend: heart rate at end of surgery. *P < 0.05 compared with HR0. †P < 0.05 compared with Group S.

Mentions: The SBP and DBP were not significantly different and they were similar with the progress of time (P > 0.05). Comparing intervals, Group R compared to Group S had low SBP and DBP 10 min and 15 min post-intubation, but there were no differences afterwards (Fig. 4 and 5). HR values were significantly different (P < 0.05). Although Group R, compared to Group S, had lower HR values from 10 min post-intubation (Fig. 6) (P < 0.05), this was clinically insignificant. Neither group required drug administration for intra-operative hemodynamic stabilization.


Effect of remifentanil on consumption of sevoflurane in entropy monitored general anesthesia.

Kim HT, Heo HE, Kwon YE, Lee MJ - Korean J Anesthesiol (2010)

Change of heart rate. Values are expressed as mean ± SD. Group S: group received normal saline. Group R: group received remifentanil (0.1 µg/kg/min). HR0-25: heart rate at 0-25 minute after intubation, HRss: heart rate at skin suture, HRend: heart rate at end of surgery. *P < 0.05 compared with HR0. †P < 0.05 compared with Group S.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2966703&req=5

Figure 6: Change of heart rate. Values are expressed as mean ± SD. Group S: group received normal saline. Group R: group received remifentanil (0.1 µg/kg/min). HR0-25: heart rate at 0-25 minute after intubation, HRss: heart rate at skin suture, HRend: heart rate at end of surgery. *P < 0.05 compared with HR0. †P < 0.05 compared with Group S.
Mentions: The SBP and DBP were not significantly different and they were similar with the progress of time (P > 0.05). Comparing intervals, Group R compared to Group S had low SBP and DBP 10 min and 15 min post-intubation, but there were no differences afterwards (Fig. 4 and 5). HR values were significantly different (P < 0.05). Although Group R, compared to Group S, had lower HR values from 10 min post-intubation (Fig. 6) (P < 0.05), this was clinically insignificant. Neither group required drug administration for intra-operative hemodynamic stabilization.

Bottom Line: ET was significantly lower in the R group than the S group.There were no significant differences in entropy value between R and S groups.Entropy monitored titration of sevoflurane with remifentanil administration decreased ET with stable hemodynamics.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center, Jeonju, Korea.

ABSTRACT

Background: Monitoring of anesthetic depth is important for successful general anesthesia. It is well known that entropy or BIS monitoring assisted titration of anesthetic drugs decreases their consumption. This study evaluated the effect of remifentanil on consumption of sevoflurane during entropy monitored general anesthesia.

Methods: Patients were randomly assigned to two groups. The R group was administered 0.1 µg/kg/min of remifentanil and inhaled sevoflurane, while the S group was administered only inhaled sevoflurane. Anesthesia was maintained using sevoflurane with nitrous oxide, and entropy was monitored. In both groups, the concentration of sevoflurane was adjusted to keep the state entropy (SE) value between 40 and 60. End-tidal sevoflurane concentration (ET), entropy value, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 5 minute intervals, during a 25 minute period after intubation, skin suture and the end of surgery.

Results: ET was significantly lower in the R group than the S group. There were no significant differences in entropy value between R and S groups.

Conclusions: Entropy monitored titration of sevoflurane with remifentanil administration decreased ET with stable hemodynamics.

No MeSH data available.


Related in: MedlinePlus