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An outbreak of dengue fever in St. Croix (US Virgin Islands), 2005.

Mohammed H, Ramos M, Armstrong J, Muñoz-Jordán J, Arnold-Lewis KO, Ayala A, Clark GG, Tull ES, Beatty ME - PLoS ONE (2010)

Bottom Line: Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls).The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.

View Article: PubMed Central - PubMed

Affiliation: Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico. hamohammed@rossvet.edu.kn

ABSTRACT

Background: Periodic outbreaks of dengue fever occur in the United States Virgin Islands. In June 2005, an outbreak of dengue virus (DENV) serotype-2 with cases of dengue hemorrhagic fever (DHF) was detected in St. Croix, US Virgin Islands. The objective of this report is to describe this outbreak of DENV-2 and the findings of a case-control study examining risk factors for DHF.

Methodology/principal findings: This is the largest dengue outbreak ever recorded in St. Croix, with 331 suspected dengue cases reported island-wide during 2005 (62.2 cases/10,000 population); 54% were hospitalized, 21% had at least one hemorrhagic manifestation, 28% had thrombocytopenia, 5% had DHF and 1 patient died. Eighty-nine laboratory-positive hospitalized patients were identified. Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls). The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).

Conclusions/significance: During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.

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Proportion of DF and DHF cases in the case-control study by age-group.
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pone-0013729-g002: Proportion of DF and DHF cases in the case-control study by age-group.

Mentions: Eighty-nine laboratory-positive patients were identified from the JFL Hospital including 15 (17%) who met WHO criteria for DHF (cases) and 74 (83%) who did not (controls). Of these 89 patients, 30% had at least one hemorrhagic manifestation. Of the 15 DHF cases, a single patient experienced DHF grade III and the remainder had grade II. [1] There was no significant difference in the median length of hospital stay between cases and controls (4.5 vs. 4.0 days, p = 0.74). Selected clinical characteristics of cases and controls are compared in Table 1. Cases and controls were similar with respect to gender, race, and history of hypertension, diabetes, or asthma. On bivariate analysis, age was the only variable significantly associated with DHF (p = 0.03). Similarly, in the final multivariable model (Table 2), age was the only variable associated with DHF (OR [95% CI]: 1.033 [1.003,1.064]). As age was considered as a continuous variable in the model, its OR is interpreted as follows: for every additional year of life, there would be a 3% increase in the odds of acquiring DHF. As demonstrated in table 3 and figure 2, there was a higher proportion of DHF cases in those above the age of 40.


An outbreak of dengue fever in St. Croix (US Virgin Islands), 2005.

Mohammed H, Ramos M, Armstrong J, Muñoz-Jordán J, Arnold-Lewis KO, Ayala A, Clark GG, Tull ES, Beatty ME - PLoS ONE (2010)

Proportion of DF and DHF cases in the case-control study by age-group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2965679&req=5

pone-0013729-g002: Proportion of DF and DHF cases in the case-control study by age-group.
Mentions: Eighty-nine laboratory-positive patients were identified from the JFL Hospital including 15 (17%) who met WHO criteria for DHF (cases) and 74 (83%) who did not (controls). Of these 89 patients, 30% had at least one hemorrhagic manifestation. Of the 15 DHF cases, a single patient experienced DHF grade III and the remainder had grade II. [1] There was no significant difference in the median length of hospital stay between cases and controls (4.5 vs. 4.0 days, p = 0.74). Selected clinical characteristics of cases and controls are compared in Table 1. Cases and controls were similar with respect to gender, race, and history of hypertension, diabetes, or asthma. On bivariate analysis, age was the only variable significantly associated with DHF (p = 0.03). Similarly, in the final multivariable model (Table 2), age was the only variable associated with DHF (OR [95% CI]: 1.033 [1.003,1.064]). As age was considered as a continuous variable in the model, its OR is interpreted as follows: for every additional year of life, there would be a 3% increase in the odds of acquiring DHF. As demonstrated in table 3 and figure 2, there was a higher proportion of DHF cases in those above the age of 40.

Bottom Line: Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls).The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.

View Article: PubMed Central - PubMed

Affiliation: Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico. hamohammed@rossvet.edu.kn

ABSTRACT

Background: Periodic outbreaks of dengue fever occur in the United States Virgin Islands. In June 2005, an outbreak of dengue virus (DENV) serotype-2 with cases of dengue hemorrhagic fever (DHF) was detected in St. Croix, US Virgin Islands. The objective of this report is to describe this outbreak of DENV-2 and the findings of a case-control study examining risk factors for DHF.

Methodology/principal findings: This is the largest dengue outbreak ever recorded in St. Croix, with 331 suspected dengue cases reported island-wide during 2005 (62.2 cases/10,000 population); 54% were hospitalized, 21% had at least one hemorrhagic manifestation, 28% had thrombocytopenia, 5% had DHF and 1 patient died. Eighty-nine laboratory-positive hospitalized patients were identified. Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls). The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).

Conclusions/significance: During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.

Show MeSH
Related in: MedlinePlus