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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen HP, Björkqvist M, Bode FJ, Stephan M, von Hörsten S - PLoS Curr (2010)

Bottom Line: Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls.Moreover, we observed a high interindividual variability.Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, University of Tuebingen; Lund University, Sweden; Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany; Hannover Medical School and Friedrich-Alexander-University Erlangen-Nürnberg.

ABSTRACT
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

No MeSH data available.


Related in: MedlinePlus

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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen HP, Björkqvist M, Bode FJ, Stephan M, von Hörsten S - PLoS Curr (2010)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2964049&req=5

Bottom Line: Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls.Moreover, we observed a high interindividual variability.Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, University of Tuebingen; Lund University, Sweden; Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany; Hannover Medical School and Friedrich-Alexander-University Erlangen-Nürnberg.

ABSTRACT
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

No MeSH data available.


Related in: MedlinePlus