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Sarcomatoid carcinoma of the urinary bladder: a clinicopathological study of 4 cases and a review of the literature.

Stamatiou K, Galariotis N, Michailidis I, Petrakopoulou N, Moustou H, Zizi-Sermpetzoglou A - Korean J Urol (2010)

Bottom Line: Three out of 4 patients were males and one female.The median age was 72.8 years (range, 60-79 years).Despite treatment all patients died within 22 months of the diagnosis of SC.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Tzaneio General Hospital of Pireas, Pireas, Greece.

ABSTRACT
Sarcomatoid carcinoma (SC) of urinary bladder is a rare tumor exhibiting aggressive behavior. Here we are reviewing the pathologic and clinical characteristics of 4 consecutive cases of this rare tumor. Three out of 4 patients were males and one female. The median age was 72.8 years (range, 60-79 years). Patients underwent transurethral resection of bladder tumor and the diagnosis of bladder SC was established on the pathologic examination of the resected bladder tissue. Despite treatment all patients died within 22 months of the diagnosis of SC. SC of the bladder are true biphasic malignant neoplasm exhibiting morphologic and immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. The aggressive of the tumor precludes radical therapy whenever possible, since adjuvant therapy seems to have little effect.

No MeSH data available.


Related in: MedlinePlus

(A) Transitional cell grade 3 carcinoma. Beneath that can be seen a spindle cell neoplasm with a sarcomatous appearance (H&E, ×100). (B) Immunoperoxidase stain with vimentin showing immunoreactivity in the spindle cell component (Vim, ×100).
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Figure 1: (A) Transitional cell grade 3 carcinoma. Beneath that can be seen a spindle cell neoplasm with a sarcomatous appearance (H&E, ×100). (B) Immunoperoxidase stain with vimentin showing immunoreactivity in the spindle cell component (Vim, ×100).

Mentions: The biopsy specimen had an overall volume of 70 cc. It consisted partly of papillary and partly of solid, transitional cell grade 3 carcinoma. Beneath that was a spindle cell neoplasm with a sarcomatous appearance (Fig. 1A). The spindle cell component showed mild nuclear pleomorphism and severe mitotic activity. In immunohistochemistry, the epithelial component was stained for P63. The spindle cell component was positively stained for vimentin (Fig. 1B) with a small subset of these cells being at least focally positive for cytokeratin. The stains for HHF-35, SMA, and desmin were negative.


Sarcomatoid carcinoma of the urinary bladder: a clinicopathological study of 4 cases and a review of the literature.

Stamatiou K, Galariotis N, Michailidis I, Petrakopoulou N, Moustou H, Zizi-Sermpetzoglou A - Korean J Urol (2010)

(A) Transitional cell grade 3 carcinoma. Beneath that can be seen a spindle cell neoplasm with a sarcomatous appearance (H&E, ×100). (B) Immunoperoxidase stain with vimentin showing immunoreactivity in the spindle cell component (Vim, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2963788&req=5

Figure 1: (A) Transitional cell grade 3 carcinoma. Beneath that can be seen a spindle cell neoplasm with a sarcomatous appearance (H&E, ×100). (B) Immunoperoxidase stain with vimentin showing immunoreactivity in the spindle cell component (Vim, ×100).
Mentions: The biopsy specimen had an overall volume of 70 cc. It consisted partly of papillary and partly of solid, transitional cell grade 3 carcinoma. Beneath that was a spindle cell neoplasm with a sarcomatous appearance (Fig. 1A). The spindle cell component showed mild nuclear pleomorphism and severe mitotic activity. In immunohistochemistry, the epithelial component was stained for P63. The spindle cell component was positively stained for vimentin (Fig. 1B) with a small subset of these cells being at least focally positive for cytokeratin. The stains for HHF-35, SMA, and desmin were negative.

Bottom Line: Three out of 4 patients were males and one female.The median age was 72.8 years (range, 60-79 years).Despite treatment all patients died within 22 months of the diagnosis of SC.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Tzaneio General Hospital of Pireas, Pireas, Greece.

ABSTRACT
Sarcomatoid carcinoma (SC) of urinary bladder is a rare tumor exhibiting aggressive behavior. Here we are reviewing the pathologic and clinical characteristics of 4 consecutive cases of this rare tumor. Three out of 4 patients were males and one female. The median age was 72.8 years (range, 60-79 years). Patients underwent transurethral resection of bladder tumor and the diagnosis of bladder SC was established on the pathologic examination of the resected bladder tissue. Despite treatment all patients died within 22 months of the diagnosis of SC. SC of the bladder are true biphasic malignant neoplasm exhibiting morphologic and immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. The aggressive of the tumor precludes radical therapy whenever possible, since adjuvant therapy seems to have little effect.

No MeSH data available.


Related in: MedlinePlus