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Diffusion-weighted magnetic resonance imaging in acute reversible toxic leukoencephalopathy: A report of two cases.

Sivasubramanian S, Moorthy S, Sreekumar K, Kannan RR - Indian J Radiol Imaging (2010)

Bottom Line: It may reverse clinically if the offending agent is withdrawn or the underlying condition is treated.However, demonstration of reversibility on imaging, especially with diffusion-weighted MRI, has been reported only very recently.We report two such cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Amrita Institute of Medical Sciences, Elamakkara, Cochin - 682 041, India.

ABSTRACT
Acute toxic leukoencephalopathy may be caused by endogenous or exogenous toxins. It may reverse clinically if the offending agent is withdrawn or the underlying condition is treated. However, demonstration of reversibility on imaging, especially with diffusion-weighted MRI, has been reported only very recently. We report two such cases.

No MeSH data available.


Related in: MedlinePlus

MRI. Axial diffusion-weighted (b1000) image (A) shows significant restriction of diffusion (arrows) in the frontal lobe white matter and the splenium of the corpus callosum (not shown). Corresponding ADC image (B) shows decreased ADC, as evident by the dark signal (arrows) in the region of reduced diffusion (ADC: 350 – 400 10-3 mm2/s). Axial FLAIR image (C) shows no significant changes in the region of reduced diffusion. Follow-up MRI (diffusionweighted imaging) (D) shows resolution of the white matter changes (ADC: 650 – 700 10-3 mm2/s)
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Figure 0002: MRI. Axial diffusion-weighted (b1000) image (A) shows significant restriction of diffusion (arrows) in the frontal lobe white matter and the splenium of the corpus callosum (not shown). Corresponding ADC image (B) shows decreased ADC, as evident by the dark signal (arrows) in the region of reduced diffusion (ADC: 350 – 400 10-3 mm2/s). Axial FLAIR image (C) shows no significant changes in the region of reduced diffusion. Follow-up MRI (diffusionweighted imaging) (D) shows resolution of the white matter changes (ADC: 650 – 700 10-3 mm2/s)

Mentions: MRI during the episode showed significant diffusion restriction [Figure 2A], with reduced ADC values [Figure 2B] in the frontal white matter bilaterally and the splenium of the corpus callosum (350 – 400 in the involved white matter, compared with 800 – 950 in the unaffected white matter). FLAIR images showed no signal changes [Figure 2C]. No abnormal enhancement was seen. Significant resolution of the findings was seen on the diffusion-weighted images on an MRI done after 3 days (ADC values were in the range of 650 – 700) [Figure 2D].


Diffusion-weighted magnetic resonance imaging in acute reversible toxic leukoencephalopathy: A report of two cases.

Sivasubramanian S, Moorthy S, Sreekumar K, Kannan RR - Indian J Radiol Imaging (2010)

MRI. Axial diffusion-weighted (b1000) image (A) shows significant restriction of diffusion (arrows) in the frontal lobe white matter and the splenium of the corpus callosum (not shown). Corresponding ADC image (B) shows decreased ADC, as evident by the dark signal (arrows) in the region of reduced diffusion (ADC: 350 – 400 10-3 mm2/s). Axial FLAIR image (C) shows no significant changes in the region of reduced diffusion. Follow-up MRI (diffusionweighted imaging) (D) shows resolution of the white matter changes (ADC: 650 – 700 10-3 mm2/s)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2963759&req=5

Figure 0002: MRI. Axial diffusion-weighted (b1000) image (A) shows significant restriction of diffusion (arrows) in the frontal lobe white matter and the splenium of the corpus callosum (not shown). Corresponding ADC image (B) shows decreased ADC, as evident by the dark signal (arrows) in the region of reduced diffusion (ADC: 350 – 400 10-3 mm2/s). Axial FLAIR image (C) shows no significant changes in the region of reduced diffusion. Follow-up MRI (diffusionweighted imaging) (D) shows resolution of the white matter changes (ADC: 650 – 700 10-3 mm2/s)
Mentions: MRI during the episode showed significant diffusion restriction [Figure 2A], with reduced ADC values [Figure 2B] in the frontal white matter bilaterally and the splenium of the corpus callosum (350 – 400 in the involved white matter, compared with 800 – 950 in the unaffected white matter). FLAIR images showed no signal changes [Figure 2C]. No abnormal enhancement was seen. Significant resolution of the findings was seen on the diffusion-weighted images on an MRI done after 3 days (ADC values were in the range of 650 – 700) [Figure 2D].

Bottom Line: It may reverse clinically if the offending agent is withdrawn or the underlying condition is treated.However, demonstration of reversibility on imaging, especially with diffusion-weighted MRI, has been reported only very recently.We report two such cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Amrita Institute of Medical Sciences, Elamakkara, Cochin - 682 041, India.

ABSTRACT
Acute toxic leukoencephalopathy may be caused by endogenous or exogenous toxins. It may reverse clinically if the offending agent is withdrawn or the underlying condition is treated. However, demonstration of reversibility on imaging, especially with diffusion-weighted MRI, has been reported only very recently. We report two such cases.

No MeSH data available.


Related in: MedlinePlus