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Multimodality imaging of chronic ischemia.

Ishikawa K, Ladage D, Rapti K, Fernandez-Friera L, Maria Garcia-Lopez A, Sanz J, Hajjar RJ, Kawase Y, Garcia MJ - Cardiol Res Pract (2010)

Bottom Line: Although ischemic cardiomyopathy is commonly caused by chronic obstructive coronary disease, the mechanism of the cause is still under investigation.We present echocardiographic strain, magnetic resonance, and histology findings in a chronic ischemia model in preclinical study.This case illustrates the features of multimodality imaging in chronic obstructive coronary disease and gives us great insight into understanding the mechanism of ischemic cardiomyopathy.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Research Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, P. O. Box 1030, New York, NY 10029-6574, USA.

ABSTRACT
Although ischemic cardiomyopathy is commonly caused by chronic obstructive coronary disease, the mechanism of the cause is still under investigation. We present echocardiographic strain, magnetic resonance, and histology findings in a chronic ischemia model in preclinical study. This case illustrates the features of multimodality imaging in chronic obstructive coronary disease and gives us great insight into understanding the mechanism of ischemic cardiomyopathy.

No MeSH data available.


Related in: MedlinePlus

Corresponding short axis and long axis images obtained by CMR. T2w-CMR images showed uptake in the anterior wall (arrows), indicating myocardial edema from ischemia mainly in subendocardium (upper row). However, no specific change was found in delayed enhancement images (lower row). CMR: cardiac magnetic resonance DE: delayed enhancement.
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fig3: Corresponding short axis and long axis images obtained by CMR. T2w-CMR images showed uptake in the anterior wall (arrows), indicating myocardial edema from ischemia mainly in subendocardium (upper row). However, no specific change was found in delayed enhancement images (lower row). CMR: cardiac magnetic resonance DE: delayed enhancement.

Mentions: Echocardiography at 2 months confirmed this abnormality (EF 58%). Using prototype Q-lab software (Philips Medical Systems, Andover, MA), two-dimensional images were analyzed for strain analysis using a speckle-tracking algorithm. Circumferential and radial strain (CS and RS, resp.) were analyzed at the level of papillary muscles, and both strain rates at anterior region showed relatively decreased but sustained value compared with other regions. (mean CS −19% versus −26%, mean RS 30% versus 46%, resp.) (Figure 2). After the echocardiography, the pig was transported to the magnetic resonance (MR) facility under anesthesia. Using a 1.5 Tesla magnet (Sonata, Siemens Medical Solutions, Erlangen, Germany), and with electrocardiographic gating, the same plane as during transthoracic echocardiography study was obtained. Delayed enhancement imaging was performed 15 minutes after the administration of 0.2 mmol/kg gadopentetate dimeglumine. T2-weighted image revealed limited intensified area in the subendocardium layer of the anterior wall, which indicates the presence of edema. However, no delayed enhancement was detected at the same region (Figure 3).


Multimodality imaging of chronic ischemia.

Ishikawa K, Ladage D, Rapti K, Fernandez-Friera L, Maria Garcia-Lopez A, Sanz J, Hajjar RJ, Kawase Y, Garcia MJ - Cardiol Res Pract (2010)

Corresponding short axis and long axis images obtained by CMR. T2w-CMR images showed uptake in the anterior wall (arrows), indicating myocardial edema from ischemia mainly in subendocardium (upper row). However, no specific change was found in delayed enhancement images (lower row). CMR: cardiac magnetic resonance DE: delayed enhancement.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2963130&req=5

fig3: Corresponding short axis and long axis images obtained by CMR. T2w-CMR images showed uptake in the anterior wall (arrows), indicating myocardial edema from ischemia mainly in subendocardium (upper row). However, no specific change was found in delayed enhancement images (lower row). CMR: cardiac magnetic resonance DE: delayed enhancement.
Mentions: Echocardiography at 2 months confirmed this abnormality (EF 58%). Using prototype Q-lab software (Philips Medical Systems, Andover, MA), two-dimensional images were analyzed for strain analysis using a speckle-tracking algorithm. Circumferential and radial strain (CS and RS, resp.) were analyzed at the level of papillary muscles, and both strain rates at anterior region showed relatively decreased but sustained value compared with other regions. (mean CS −19% versus −26%, mean RS 30% versus 46%, resp.) (Figure 2). After the echocardiography, the pig was transported to the magnetic resonance (MR) facility under anesthesia. Using a 1.5 Tesla magnet (Sonata, Siemens Medical Solutions, Erlangen, Germany), and with electrocardiographic gating, the same plane as during transthoracic echocardiography study was obtained. Delayed enhancement imaging was performed 15 minutes after the administration of 0.2 mmol/kg gadopentetate dimeglumine. T2-weighted image revealed limited intensified area in the subendocardium layer of the anterior wall, which indicates the presence of edema. However, no delayed enhancement was detected at the same region (Figure 3).

Bottom Line: Although ischemic cardiomyopathy is commonly caused by chronic obstructive coronary disease, the mechanism of the cause is still under investigation.We present echocardiographic strain, magnetic resonance, and histology findings in a chronic ischemia model in preclinical study.This case illustrates the features of multimodality imaging in chronic obstructive coronary disease and gives us great insight into understanding the mechanism of ischemic cardiomyopathy.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Research Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, P. O. Box 1030, New York, NY 10029-6574, USA.

ABSTRACT
Although ischemic cardiomyopathy is commonly caused by chronic obstructive coronary disease, the mechanism of the cause is still under investigation. We present echocardiographic strain, magnetic resonance, and histology findings in a chronic ischemia model in preclinical study. This case illustrates the features of multimodality imaging in chronic obstructive coronary disease and gives us great insight into understanding the mechanism of ischemic cardiomyopathy.

No MeSH data available.


Related in: MedlinePlus