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Hyperbaric oxygen exposure reduces age-related decrease in oxidative capacity of the tibialis anterior muscle in mice.

Nishizaka T, Nagatomo F, Fujino H, Nomura T, Sano T, Higuchi K, Takeda I, Ishihara A - Enzyme Res (2010)

Bottom Line: Furthermore, the SDH activities of type IIA and type IIB fibers in the muscle were determined using quantitative histochemical analysis.Similar results were observed in both type IIA and type IIB fibers in the muscle.We conclude that exposure to hyperbaric oxygen used in this study reduces the age-related decrease in the oxidative capacity of skeletal muscles.

View Article: PubMed Central - PubMed

Affiliation: Beauty Care Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.

ABSTRACT
The effects of exposure to hyperbaric oxygen on the oxidative capacity of the skeletal muscles in mice at different ages were investigated. We exposed 5-, 34-, 55-, and 88-week-old mice to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks. The activities of succinate dehydrogenase (SDH), which is a mitochondrial marker enzyme, of the tibialis anterior muscle in hyperbaric mice were compared with those in age-matched mice under normobaric conditions (21% oxygen at 760 mmHg). Furthermore, the SDH activities of type IIA and type IIB fibers in the muscle were determined using quantitative histochemical analysis. The SDH activity of the muscle in normobaric mice decreased with age. Similar results were observed in both type IIA and type IIB fibers in the muscle. The decrease in the SDH activity of the muscle was reduced in hyperbaric mice at 57 and 90 weeks. The decreased SDH activities of type IIA and type IIB fibers were reduced in hyperbaric mice at 90 weeks and at 57 and 90 weeks, respectively. We conclude that exposure to hyperbaric oxygen used in this study reduces the age-related decrease in the oxidative capacity of skeletal muscles.

No MeSH data available.


Related in: MedlinePlus

Body weights (a) and tibialis anterior muscle weights (b) of the normobaric and hyperbaric groups at different ages.  Data are represented as the mean and standard deviation determined from six animals.  The mice in the hyperbaric group were exposed to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks.  aP < .05 compared with the corresponding group at 7 weeks; bP < .05 compared with the corresponding groups at 7, 36, and 57 weeks; cP < .05 compared with the corresponding group at 57 weeks.
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fig2: Body weights (a) and tibialis anterior muscle weights (b) of the normobaric and hyperbaric groups at different ages. Data are represented as the mean and standard deviation determined from six animals. The mice in the hyperbaric group were exposed to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks. aP < .05 compared with the corresponding group at 7 weeks; bP < .05 compared with the corresponding groups at 7, 36, and 57 weeks; cP < .05 compared with the corresponding group at 57 weeks.

Mentions: An age-related increase in body weight was observed in the normobaric groups; the body weights at 36 and 57 weeks were greater than that at 7 weeks, and the body weight at 90 weeks was the greatest among the groups (Figure 2(a)). These results were similar in the hyperbaric groups.


Hyperbaric oxygen exposure reduces age-related decrease in oxidative capacity of the tibialis anterior muscle in mice.

Nishizaka T, Nagatomo F, Fujino H, Nomura T, Sano T, Higuchi K, Takeda I, Ishihara A - Enzyme Res (2010)

Body weights (a) and tibialis anterior muscle weights (b) of the normobaric and hyperbaric groups at different ages.  Data are represented as the mean and standard deviation determined from six animals.  The mice in the hyperbaric group were exposed to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks.  aP < .05 compared with the corresponding group at 7 weeks; bP < .05 compared with the corresponding groups at 7, 36, and 57 weeks; cP < .05 compared with the corresponding group at 57 weeks.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2962912&req=5

fig2: Body weights (a) and tibialis anterior muscle weights (b) of the normobaric and hyperbaric groups at different ages. Data are represented as the mean and standard deviation determined from six animals. The mice in the hyperbaric group were exposed to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks. aP < .05 compared with the corresponding group at 7 weeks; bP < .05 compared with the corresponding groups at 7, 36, and 57 weeks; cP < .05 compared with the corresponding group at 57 weeks.
Mentions: An age-related increase in body weight was observed in the normobaric groups; the body weights at 36 and 57 weeks were greater than that at 7 weeks, and the body weight at 90 weeks was the greatest among the groups (Figure 2(a)). These results were similar in the hyperbaric groups.

Bottom Line: Furthermore, the SDH activities of type IIA and type IIB fibers in the muscle were determined using quantitative histochemical analysis.Similar results were observed in both type IIA and type IIB fibers in the muscle.We conclude that exposure to hyperbaric oxygen used in this study reduces the age-related decrease in the oxidative capacity of skeletal muscles.

View Article: PubMed Central - PubMed

Affiliation: Beauty Care Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.

ABSTRACT
The effects of exposure to hyperbaric oxygen on the oxidative capacity of the skeletal muscles in mice at different ages were investigated. We exposed 5-, 34-, 55-, and 88-week-old mice to 36% oxygen at 950 mmHg for 6 hours per day for 2 weeks. The activities of succinate dehydrogenase (SDH), which is a mitochondrial marker enzyme, of the tibialis anterior muscle in hyperbaric mice were compared with those in age-matched mice under normobaric conditions (21% oxygen at 760 mmHg). Furthermore, the SDH activities of type IIA and type IIB fibers in the muscle were determined using quantitative histochemical analysis. The SDH activity of the muscle in normobaric mice decreased with age. Similar results were observed in both type IIA and type IIB fibers in the muscle. The decrease in the SDH activity of the muscle was reduced in hyperbaric mice at 57 and 90 weeks. The decreased SDH activities of type IIA and type IIB fibers were reduced in hyperbaric mice at 90 weeks and at 57 and 90 weeks, respectively. We conclude that exposure to hyperbaric oxygen used in this study reduces the age-related decrease in the oxidative capacity of skeletal muscles.

No MeSH data available.


Related in: MedlinePlus