Limits...
Molecular mechanisms of tiling and self-avoidance in neural development.

Cameron S, Rao Y - Mol Brain (2010)

Bottom Line: Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance.By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner.These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.

View Article: PubMed Central - HTML - PubMed

Affiliation: McGill Centre for Research in Neuroscience, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

ABSTRACT
Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance. By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner. These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.

Show MeSH

Related in: MedlinePlus

Proposed models for the action of Tutl. The homophilic binding between two Tutl proteins on opposing cell surface may be mediated by one or more of its Ig domains. Tutl may mediate homotypic repulsion. Alternatively, Tutl may mediate de-adhesion by antagonizing the function of certain R7-specific cell adhesion molecules. Circles, Ig domains; Rectangles, fibronectin type-III repeats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2959082&req=5

Figure 3: Proposed models for the action of Tutl. The homophilic binding between two Tutl proteins on opposing cell surface may be mediated by one or more of its Ig domains. Tutl may mediate homotypic repulsion. Alternatively, Tutl may mediate de-adhesion by antagonizing the function of certain R7-specific cell adhesion molecules. Circles, Ig domains; Rectangles, fibronectin type-III repeats.

Mentions: The Drosophila Turtle (Tutl) protein is the second cell surface determinant shown to regulate homotypic interaction in tiling and self-avoidance [44,45]. Tutl is a member of the evolutionarily conserved Turtle/Dasm1/IgSF9 subfamily of the Ig-superfamily, which share a common architecture comprising of an extracellular region containing five Ig domains and two fibronectin type-III repeats, a single transmembrane region, and a cytoplasmic domain [46-48] (Fig. 3).


Molecular mechanisms of tiling and self-avoidance in neural development.

Cameron S, Rao Y - Mol Brain (2010)

Proposed models for the action of Tutl. The homophilic binding between two Tutl proteins on opposing cell surface may be mediated by one or more of its Ig domains. Tutl may mediate homotypic repulsion. Alternatively, Tutl may mediate de-adhesion by antagonizing the function of certain R7-specific cell adhesion molecules. Circles, Ig domains; Rectangles, fibronectin type-III repeats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2959082&req=5

Figure 3: Proposed models for the action of Tutl. The homophilic binding between two Tutl proteins on opposing cell surface may be mediated by one or more of its Ig domains. Tutl may mediate homotypic repulsion. Alternatively, Tutl may mediate de-adhesion by antagonizing the function of certain R7-specific cell adhesion molecules. Circles, Ig domains; Rectangles, fibronectin type-III repeats.
Mentions: The Drosophila Turtle (Tutl) protein is the second cell surface determinant shown to regulate homotypic interaction in tiling and self-avoidance [44,45]. Tutl is a member of the evolutionarily conserved Turtle/Dasm1/IgSF9 subfamily of the Ig-superfamily, which share a common architecture comprising of an extracellular region containing five Ig domains and two fibronectin type-III repeats, a single transmembrane region, and a cytoplasmic domain [46-48] (Fig. 3).

Bottom Line: Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance.By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner.These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.

View Article: PubMed Central - HTML - PubMed

Affiliation: McGill Centre for Research in Neuroscience, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.

ABSTRACT
Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance. By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner. These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.

Show MeSH
Related in: MedlinePlus