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Clinical significance of Polycomb gene expression in brain tumors.

Crea F, Hurt EM, Farrar WL - Mol. Cancer (2010)

Bottom Line: Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal.In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes.In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

ABSTRACT
Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and their effects on cellular pathways have not been investigated. For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors. EZH2 expression increases with tumor grade in adult and pediatric brain tumors, and is a poor prognostic factor. In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes. In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors.

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EZH2 expression in neurological tumors. A, B: EZH2 is overexpressed in higher grade tumors. C, D: EZH2 overexpression is associated to poor prognosis in human glioblastoma (Oncomine database).
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Figure 1: EZH2 expression in neurological tumors. A, B: EZH2 is overexpressed in higher grade tumors. C, D: EZH2 overexpression is associated to poor prognosis in human glioblastoma (Oncomine database).

Mentions: Table 1 summarizes differentially expressed PcG genes in normal brain, brain tumors and specific tumor histologies. Surprisingly, some PRC1 components (BMI1, CBX2, CBX7) were downreglated in glioblastoma compared to normal brain. Other PRC1 members (CBX7, PCGF6) were selectively expressed in lower grade gliomas. In contrast, the PRC2 components EZH2 and SUZ12 were always overexpressed in tumors compared to normal neural tissue. In addition, these 3 independent studies all showed a highly significant correlation between EZH2 overexpression and gliomas. Moreover, EZH2 expression significantly increased with tumor grade in both adult and pediatric brain tumors (Figure 1A, B).


Clinical significance of Polycomb gene expression in brain tumors.

Crea F, Hurt EM, Farrar WL - Mol. Cancer (2010)

EZH2 expression in neurological tumors. A, B: EZH2 is overexpressed in higher grade tumors. C, D: EZH2 overexpression is associated to poor prognosis in human glioblastoma (Oncomine database).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2958980&req=5

Figure 1: EZH2 expression in neurological tumors. A, B: EZH2 is overexpressed in higher grade tumors. C, D: EZH2 overexpression is associated to poor prognosis in human glioblastoma (Oncomine database).
Mentions: Table 1 summarizes differentially expressed PcG genes in normal brain, brain tumors and specific tumor histologies. Surprisingly, some PRC1 components (BMI1, CBX2, CBX7) were downreglated in glioblastoma compared to normal brain. Other PRC1 members (CBX7, PCGF6) were selectively expressed in lower grade gliomas. In contrast, the PRC2 components EZH2 and SUZ12 were always overexpressed in tumors compared to normal neural tissue. In addition, these 3 independent studies all showed a highly significant correlation between EZH2 overexpression and gliomas. Moreover, EZH2 expression significantly increased with tumor grade in both adult and pediatric brain tumors (Figure 1A, B).

Bottom Line: Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal.In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes.In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

ABSTRACT
Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and their effects on cellular pathways have not been investigated. For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors. EZH2 expression increases with tumor grade in adult and pediatric brain tumors, and is a poor prognostic factor. In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes. In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors.

Show MeSH
Related in: MedlinePlus