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Cluster of Nipah virus infection, Kushtia District, Bangladesh, 2007.

Homaira N, Rahman M, Hossain MJ, Nahar N, Khan R, Rahman M, Podder G, Nahar K, Khan D, Gurley ES, Rollin PE, Comer JA, Ksiazek TG, Luby SP - PLoS ONE (2010)

Bottom Line: We identified three confirmed and five probable Nipah cases.The index case, on her third day of illness, and all the subsequent cases attended the same religious gathering.Continued surveillance and outbreak investigations will help better understand the transmission of Nipah virus and develop preventive strategies.

View Article: PubMed Central - PubMed

Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. nhomaira@icddrb.org

ABSTRACT

Objective: In March 2007, we investigated a cluster of Nipah encephalitis to identify risk factors for Nipah infection in Bangladesh.

Methods: We defined confirmed Nipah cases by the presence of IgM and IgG antibodies against Nipah virus in serum. Case-patients, who resided in the same village during the outbreak period but died before serum could be collected, were classified as probable cases.

Results: We identified three confirmed and five probable Nipah cases. There was a single index case. Five of the secondary cases came in close physical contact to the index case when she was ill. Case-patients were more likely to have physical contact with the index case (71% cases versus 0% controls, p = <0.001). The index case, on her third day of illness, and all the subsequent cases attended the same religious gathering. For three probable cases including the index case, we could not identify any known risk factors for Nipah infection such as physical contact with Nipah case-patients, consumption of raw date palm juice, or contact with sick animals or fruit bats.

Conclusion: Though person-to-person transmission remains an important mode of transmission for Nipah infection, we could not confirm the source of infection for three of the probable Nipah case-patients. Continued surveillance and outbreak investigations will help better understand the transmission of Nipah virus and develop preventive strategies.

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Related in: MedlinePlus

Distribution of Nipah cases by date of onset of illness, March-April 2007.
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pone-0013570-g001: Distribution of Nipah cases by date of onset of illness, March-April 2007.

Mentions: All the cases were clustered in time. The index case developed illness on March 17, 2007, followed by a single secondary wave of illness 12–16 days later (Figure 1). The mean age of the case-patients was 38 years (range 27–55 years) and 25% were males. The mean duration between illness onset and death was 4 days (range 1–7 days) (Table 1). Among the eight Nipah case-patients; two confirmed and four probable case-patients had fever with altered mental status and or respiratory difficulty.


Cluster of Nipah virus infection, Kushtia District, Bangladesh, 2007.

Homaira N, Rahman M, Hossain MJ, Nahar N, Khan R, Rahman M, Podder G, Nahar K, Khan D, Gurley ES, Rollin PE, Comer JA, Ksiazek TG, Luby SP - PLoS ONE (2010)

Distribution of Nipah cases by date of onset of illness, March-April 2007.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958840&req=5

pone-0013570-g001: Distribution of Nipah cases by date of onset of illness, March-April 2007.
Mentions: All the cases were clustered in time. The index case developed illness on March 17, 2007, followed by a single secondary wave of illness 12–16 days later (Figure 1). The mean age of the case-patients was 38 years (range 27–55 years) and 25% were males. The mean duration between illness onset and death was 4 days (range 1–7 days) (Table 1). Among the eight Nipah case-patients; two confirmed and four probable case-patients had fever with altered mental status and or respiratory difficulty.

Bottom Line: We identified three confirmed and five probable Nipah cases.The index case, on her third day of illness, and all the subsequent cases attended the same religious gathering.Continued surveillance and outbreak investigations will help better understand the transmission of Nipah virus and develop preventive strategies.

View Article: PubMed Central - PubMed

Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. nhomaira@icddrb.org

ABSTRACT

Objective: In March 2007, we investigated a cluster of Nipah encephalitis to identify risk factors for Nipah infection in Bangladesh.

Methods: We defined confirmed Nipah cases by the presence of IgM and IgG antibodies against Nipah virus in serum. Case-patients, who resided in the same village during the outbreak period but died before serum could be collected, were classified as probable cases.

Results: We identified three confirmed and five probable Nipah cases. There was a single index case. Five of the secondary cases came in close physical contact to the index case when she was ill. Case-patients were more likely to have physical contact with the index case (71% cases versus 0% controls, p = <0.001). The index case, on her third day of illness, and all the subsequent cases attended the same religious gathering. For three probable cases including the index case, we could not identify any known risk factors for Nipah infection such as physical contact with Nipah case-patients, consumption of raw date palm juice, or contact with sick animals or fruit bats.

Conclusion: Though person-to-person transmission remains an important mode of transmission for Nipah infection, we could not confirm the source of infection for three of the probable Nipah case-patients. Continued surveillance and outbreak investigations will help better understand the transmission of Nipah virus and develop preventive strategies.

Show MeSH
Related in: MedlinePlus