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Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

De D, Chatterjee K, Ali KM, Bera TK, Ghosh D - Evid Based Complement Alternat Med (2010)

Bottom Line: Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver.Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model.Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Medical Laboratory Science and Management, (U.G.C Innovative Department), Vidyasagar University, Midnapore 721 102, West Bengal, India.

ABSTRACT
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

No MeSH data available.


Related in: MedlinePlus

Effect of aqueous-methanolic extract of S. mahagoni seed on serum high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low density lipoprotein cholesterol (VLDLc) levels in STZ-induced diabetic rat.  Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
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fig6: Effect of aqueous-methanolic extract of S. mahagoni seed on serum high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low density lipoprotein cholesterol (VLDLc) levels in STZ-induced diabetic rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.

Mentions: Other parameters of this lipid profile like serum LDLc and VLDLc levels were elevated and serum HDLc level was decreased in the diabetic control group in respect to the control. The levels of the above-mentioned parameters were recovered significantly towards the control group after treatment of the extract of S. mahagoni seed when compare with the diabetic control group (Figure 6).


Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

De D, Chatterjee K, Ali KM, Bera TK, Ghosh D - Evid Based Complement Alternat Med (2010)

Effect of aqueous-methanolic extract of S. mahagoni seed on serum high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low density lipoprotein cholesterol (VLDLc) levels in STZ-induced diabetic rat.  Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958602&req=5

fig6: Effect of aqueous-methanolic extract of S. mahagoni seed on serum high density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LDLc) and very low density lipoprotein cholesterol (VLDLc) levels in STZ-induced diabetic rat. Bar represents Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Mentions: Other parameters of this lipid profile like serum LDLc and VLDLc levels were elevated and serum HDLc level was decreased in the diabetic control group in respect to the control. The levels of the above-mentioned parameters were recovered significantly towards the control group after treatment of the extract of S. mahagoni seed when compare with the diabetic control group (Figure 6).

Bottom Line: Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver.Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model.Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Medical Laboratory Science and Management, (U.G.C Innovative Department), Vidyasagar University, Midnapore 721 102, West Bengal, India.

ABSTRACT
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

No MeSH data available.


Related in: MedlinePlus